Mouse Anti-EGFL7 (clone 18F7.v6) scFv-Fc Chimera
CAT#: VS-0425-FY102
This fusion protein targets EGFL7 (Epidermal growth factor-like domain 7), a protein involved in vascular development and angiogenesis. By modulating EGFL7 activity, it can influence blood vessel formation and has potential applications in cancer and cardiovascular diseases.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50716/118119_B_8_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50716/118119_A_7_3.jpg
Normal Tissue
Figure 3 Liver
Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50716/118119_A_8_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50716/118119_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50716/118119_A_5_6.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50716/118119_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (EFO-21, HUVEC TERT2, RPMI-8226, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000172889-EGFL7
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Specifications
- Immunogen
- Recombinant full-length human EGFL7 protein expressed in E. coli and refolded.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human EGFL7
- Species Reactivity
- Human
- Clone
- 18F7.v6
- Applications
- Inhibition
- Related Disease
- Glioma Susceptibility 1 and Colorectal Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- EGF Like Domain Multiple 7; Multiple Epidermal Growth Factor-Like Domains Protein 7; Multiple EGF-Like Domains Protein 7; Vascular Endothelial Statin; NOTCH4-Like Protein; EGF-Like Protein 7; VE-STATIN
- Gene ID
- 51162
- UniProt ID
- Q9UHF1
- Long Name
- EGF Like Domain Multiple 7
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Thr54, Thr55, and Thr190
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 6 sites, 2 O-linked glycans (5 sites)
- Protein Refseq
- XP_006717204.1; XP_011517069.1; XP_011517070.1; XP_016870284.1; XP_016870285.1
- Function
- Regulates vascular tubulogenesis in vivo.
Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-834-VHH | Recombinant Anti-Human EGFL7 VHH Single Domain Antibody | IHC, ICC, FC, FA, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-902 | Anti-Human EGFL7 Recombinant Antibody (TAB-902) | Block | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2365MZ | Recombinant Mouse Anti-Human EGFL7 Antibody | WB | Mouse antibody |
| HPAB-0001-DJB | Mouse Anti-EGFL7 Recombinant Antibody (HPAB-0001-DJB) | ELISA, WB | Mouse IgG2b |
| HPAB-0002-DJB | Mouse Anti-EGFL7 Recombinant Antibody (HPAB-0002-DJB) | ELISA, WB | Mouse IgG2b |
| HPAB-0003-DJB | Mouse Anti-EGFL7 Recombinant Antibody (HPAB-0003-DJB) | ELISA, WB | Mouse IgG2b |
| HPAB-0951WJ | Mouse Anti-EGFL7 Recombinant Antibody (clone 4F11.v1) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0001-DJB-S(P) | Mouse Anti-EGFL7 Recombinant Antibody scFv Fragment (HPAB-0001-DJB-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-0002-DJB-S(P) | Mouse Anti-EGFL7 Recombinant Antibody scFv Fragment (HPAB-0002-DJB-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-0003-DJB-S(P) | Mouse Anti-EGFL7 Recombinant Antibody; scFv Fragment (HPAB-0003-DJB-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-0951WJ-S(P) | Mouse Anti-EGFL7 Recombinant Antibody (clone 4F11.v1); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0952WJ-S(P) | Mouse Anti-EGFL7 Recombinant Antibody (clone 4F11.v17); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0001-DJB-F(E) | Mouse Anti-EGFL7 Recombinant Antibody Fab Fragment (HPAB-0001-DJB-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-0002-DJB-F(E) | Mouse Anti-EGFL7 Recombinant Antibody Fab Fragment (HPAB-0002-DJB-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-0003-DJB-F(E) | Mouse Anti-EGFL7 Recombinant Antibody; Fab Fragment (HPAB-0003-DJB-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-0951WJ-F(E) | Mouse Anti-EGFL7 Recombinant Antibody (clone 4F11.v1); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0952WJ-F(E) | Mouse Anti-EGFL7 Recombinant Antibody (clone 4F11.v17); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-902 | Afuco™ Anti-EGFL7 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-902) | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC63 | Recombinant Anti-EGFL7 (AA 66-69 x AA 88-90) Biparatopic Antibody, Tandem scFv | ELISA, WB | Tandem scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC98 | Recombinant Anti-EGFL7 Eliminating Antibody, pH-Sensitive (VS-0625-YC98) | Antigen-Sweeping In Vivo. | Mouse IgG1 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC109 | SmartAb™ Recombinant Anti-EGFL7 pH-dependent Antibody (VS-0825-YC109) | ELISA, WB | Mouse IgG2b |
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