Mouse Anti-ENTPD1 (clone mAb1) scFv-Fc Chimera (CAT#: VS-0325-FY116)
The anti-CD39 scFv-Fc antibody targets CD39, an ectonucleotidase involved in the hydrolysis of extracellular ATP and immune regulation. It is useful for studying the role of CD39 in immune tolerance, inflammation, and cancer immunotherapy.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to microtubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to microtubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/if_selected.jpg
Figure 2 IHC staining of human endometrium
(Immunohistochemical staining of human endometrium shows strong cytoplasmic positivity with a granular pattern in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79986/170655_B_5_3_selected.jpg
(Immunohistochemical staining of human endometrium shows strong cytoplasmic positivity with a granular pattern in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79986/170655_B_5_3_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_B_7_5.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_B_7_5.jpg
Figure 4 Colon
(Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Fibroblasts
Staining: Medium
Intensity: Moderate
Mucosal lymphoid cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_9_3.jpg
(Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Fibroblasts
Staining: Medium
Intensity: Moderate
Mucosal lymphoid cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_9_3.jpg
Figure 5 Placenta
(Cytotrophoblasts
Staining: High
Intensity: Strong
Quantity:>75%
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Hofbauer cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining: High
Intensity: Strong
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_1_7.jpg
(Cytotrophoblasts
Staining: High
Intensity: Strong
Quantity:>75%
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Hofbauer cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining: High
Intensity: Strong
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_1_7.jpg
Figure 6 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_9_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_9_8.jpg
Figure 7 RNA cell line category: Group enriched (HDLM-2, Karpas-707)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000138185-ENTPD1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000138185-ENTPD1
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human ENTPD1
- Species Reactivity
- Human
- Clone
- mAb1
- Applications
- Immunoassay
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- ENTPD1; CD39; Ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; Ecto-ATP diphosphohydrolase 1; Ecto-ATPDase 1; Ecto-ATPase 1; Ecto-apyrase; Lymphoid cell activation antigen; CD antigen CD39
- Gene ID
- 953
- UniProt ID
- P49961
- Long Name
- ectonucleoside triphosphate diphosphohydrolase 1
- Sequence Similarities
- Belongs to the GDA1/CD39 NTPase family.
- Cellular Localization
- Membrane; Membrane, caveola
- Post Translation Modifications
- N-glycosylated.
The N-terminus is blocked.
Palmitoylated on Cys-13; which is required for caveola targeting.
Glycosylation at Asn73, Asn227, Asn292, Asn334, Asn371, and Asn457
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect ENTP1_HUMAN (1192)
Glycosylation from GlyGen 7 sites, 29 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011538672.3; XP_011538673.1; XP_011538674.3; XP_011538675.3; XP_011538676.3
- Function
- ENTPD1 (Ectonucleoside triphosphate diphosphohydrolase 1), also known as CD39, is an enzyme that hydrolyzes ATP and ADP, modulating purinergic signaling. It plays a crucial role in immune regulation and thrombosis.
Recommended Products
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Please select product type
IgG Antibody Products
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ScFv Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2248MZ | Recombinant Mouse Anti-Human ENTPD1 Antibody (clone 33B0) | IHC-P | Mouse antibody |
| HPAB-M0475-YC | Mouse Anti-ENTPD1 Recombinant Antibody (clone mAb1) | Inhib | Mouse IgG |
| HPAB-M0476-YC | Mouse Anti-ENTPD1 Recombinant Antibody (clone mAb2) | ELISA | Mouse IgG |
| HPAB-M0477-YC | Mouse Anti-ENTPD1 Recombinant Antibody (clone mAb3) | ELISA | Mouse IgG |
| FN-160CQ | Rat Anti-Entpd1 Recombinant Antibody (clone CBL-1321) | FC, FuncS, WB | Rat IgG2b, κ |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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