Mouse Anti-FUT4 scFv-Fc Chimera (VS-0425-FY78)
CAT#: VS-0425-FY78
FUT4 (Fucosyltransferase 4) is involved in glycosylation processes. This scFv-Fc fusion protein targets FUT4 and is being explored for its potential applications in cancer therapy and other glycosylation-related diseases.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14/204_F1_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in hematopoietic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14/301_B_6_4_selected.jpg
Normal Tissue
Figure 3 Kidney
Distal tubules Staining: Low Intensity: Moderate Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16129/161283_A_7_5.jpg
Normal Tissue
Figure 4 High expression in bone marrow.
Hematopoietic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16129/161283_B_4_4.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HL-60, NB-4, THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196371-FUT4
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Specifications
- Immunogen
- Recombinant Human CD15, a 3-fucosyl-N-acetyllactosamine (Lewis x, SSEA-1) Glycan Antigen.
- Host Species
- Mouse
- Type
- Mouse IgM, scFv-Fc
- Specificity
- Human FUT4
- Species Reactivity
- Human
- Applications
- ELISA
- Related Disease
- Hodgkin's Lymphoma, Mixed Cellularity and Hodgkin's Lymphoma, Lymphocytic-Histiocytic Predominance
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Fucosyltransferase 4; Galactoside 3-L-Fucosyltransferase; Alpha (1,3) Fucosyltransferase, Myeloid-Specific; ELAM-1 Ligand Fucosyltransferase; ELAM Ligand Fucosyltransferase; Fucosyltransferase IV; FUC-TIV; FucT-IV; FCT3A; ELFT; Stage-Specific Embryonic Antigen 1
- Gene ID
- 2526
- UniProt ID
- P22083
- Long Name
- Fucosyltransferase 4
- Sequence Similarities
- Belongs to the glycosyltransferase 10 family.
- Cellular Localization
- Golgi apparatus, Membrane
- Protein Refseq
- NP_002024.1
- Function
- Isoform Short:
Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins.
Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins.
Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis.
In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE.
Isoform Long:
Does not generate Lewis X antigens.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-706 | Anti-FUT4/CD15 Recombinant Antibody (Fanolesomab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1366 | Hi-Affi™ Rabbit Anti-FUT4 Recombinant Antibody (clone DS1366AB) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FN-030CQ | Mouse Anti-FUT4 Recombinant Antibody (FN-030CQ) | FC, FuncS, IHC | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0995WJ-S(P) | Human Anti-FUT4 Recombinant Antibody (clone 3-17); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0995WJ-F(E) | Human Anti-FUT4 Recombinant Antibody (clone 3-17); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0371F | Mouse Anti-FUT4 Recombinant Antibody (ZG-0371F) | IHC, IF, ELISA | Mouse IgG |
| VS3-CJ783 | Mouse Anti-FUT4 Recombinant Antibody (clone HI98) | IF, FC | Mouse IgM |
| VS3-CJ784 | Mouse Anti-FUT4 Recombinant Antibody (clone W6D3A12) | IF, FC | Mouse IgG1 |
| VS3-FY244 | Recombinant Mouse Anti-FUT4 Antibody (clone 6C5A3) | ELISA, ICC, FC | Mouse IgG1 |
| VS4-WK185 | Mouse Anti-FUT4 Recombinant Antibody (VS4-WK185) | ELISA, IHC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY107 | AbPlus™ Anti-FUT4 Magnetic Beads (4AHI98) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC25 | Mouse Anti-FUT4 Recombinant Antibody (VS-0924-YC25) - Cancer Stem Cell Marker | WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC96 | Recombinant Anti-FUT4 Vesicular Antibody, EV Displayed (VS-0425-YC96) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2675 | Anti-FUT4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2676 | Anti-Mouse FUT4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2677 | Anti-Monkey FUT4 Immunohistochemistry Kit | IHC |
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