Mouse Anti-IL18R1 scFv-Fc Chimera (VS-0425-FY4)
CAT#: VS-0425-FY4
The Anti-IL18R1 scFv-Fc is a novel recombinant fusion protein designed to target and neutralize the interleukin 18 receptor 1 (IL18R1). Utilizing a single-chain variable fragment (scFv) fused to the Fc region of an IgG, this product combines robust binding affinity for IL18R1 with enhanced stability and extended half-life, making it an ideal candidate for therapeutic and research applications.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7615/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human stomach
Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7615/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7615/28557_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7615/28557_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7615/28557_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7615/28557_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: High Intensity: Strong Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Preleptotene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7615/28557_A_6_6.jpg
Normal Tissue
Figure 8 Appendix
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Lymphoid tissue Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7615/28557_A_3_2.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7615/28557_A_9_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (HDLM-2, HHSteC, U-937)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115604-IL18R1
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Specifications
- Immunogen
- Cells of the Hodgkin's disease-derived cell line L428 as an immunogen.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human IL-18R1
- Species Reactivity
- Human
- Applications
- Inhibition, ELISA
- Related Disease
- Autoimmune disease, Hodgkin's disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 10 ng/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 18 Receptor 1
- Gene ID
- 8809
- UniProt ID
- Q13478
- Long Name
- Interleukin 18 Receptor 1
- Sequence Similarities
- Belongs to the interleukin-1 receptor family.
- Cellular Localization
- Membrane
- Post Translation Modifications
- N-glycosylated.
N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex.
Glycosylation at Asn91, Asn102, Asn150, Asn197, Asn203, Asn236, Asn255, and Asn297
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 9 sites, 1 N-linked glycan (2 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_024308970.1; XP_024308972.1; XP_024308973.1; XP_047302123.1; XP_047302124.1
- Function
- Induced by IL12/interleukin-12 in T-cells.
Proposed to be a phenotypic marker for T-helper 1 (Th1) cells.
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Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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