Recombinant Mouse Anti-Mbp Soluble TCR (1934.4) (KIH)
CAT#: VS-0622-YF7365
Mouse TCR (1934.4) recognizes Mbp peptide (RGGASQYRPSQ) in the context of H2-IAᵘ. Soluble TCR is expressed with Knob-in-hole (KIH) strategy (scTCR-hIgG Knob, scTCR-hIgG Hole). Please note that the activity is not guaranteed.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64368/1577_H5_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
nuclear
Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2300/6024_B_9_5.jpg
Normal Tissue
Figure 3 Caudate
Glial cells
Staining:
High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2300/6024_B_8_7.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (HL-60, SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197971-MBP
❮
❯
Specifications
- Host Species
- Mouse
- Target
- Mbp
- Species Reactivity
- Mouse
- Epitope
- RGGASQYRPSQ
- MHC
- H2-IAᵘ
- Clone
- 1934.4
- Type
- Soluble TCR (KIH)
- Related Disease
- Autoimmune encephalomyelitis (EAE)
- TCR Expression Strategy
- KIH strategy: scTCR-human IgG Knob and scTCR-human IgG Hole can form heterodimer based on Knob-in-hole (KIH) strategy. The soluble TCR contains single chain TCR. With this KIH antibody production strategy, VL/VH will be replaced with Valpha-linker-Vbeta (single chain TCR).
Target
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Related Diseases
Asthma
Downloadable Resources
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Datasheet
MSDS
COA
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