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    Mouse Anti-MCAM (clone AA98) scFv-Fc Chimera (CAT#: VS-0125-FY42)

    Anti-CD146 scFv-Fc is a recombinant protein primarily used to target the CD146 protein (also known as MCAM or MUC18). CD146 is a cell surface glycoprotein that is mainly expressed on endothelial cells and certain tumor cells, involved in biological processes such as cell adhesion, proliferation, and migration. Due to its significant role in tumor progression and angiogenesis, CD146 has become a potential target in cancer therapy. The selection and application of this antibody provide new approaches for detecting and studying the function of endothelial cell surface antigens, and it may show potential application value in transplantation, immunology, and tumor treatment.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-2 OS
    Figure 1 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/2147/if_selected.jpg
    Normal Tissue
    Figure 2 Soft tissue
    Figure 2 Soft tissue
    (Fibroblasts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8848/24112_B_2_7.jpg
    Figure 3 Cerebral cortex
    Figure 3 Cerebral cortex
    (Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8848/24112_B_9_5.jpg
    Figure 4 Colon
    Figure 4 Colon
    (Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8848/24112_A_8_3.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Strong Quantity: <25%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8848/24112_A_7_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Peritubular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Low Intensity: Weak Quantity:>75%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8848/24112_A_4_6.jpg
    RNA Expression
    Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, TIME, WM-115)
    Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, TIME, WM-115)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000076706-MCAM

    Specifications

    • Host Species
    • Mouse
    • Type
    • Human IgG1, scFv-Fc
    • Species Reactivity
    • Human
    • Clone
    • AA98
    • Applications
    • ELISA, Flow Cytometry, Inhibition, Immunohistochemistry-Frozen, Western Blot, Immunoprecipitation
    • Related Disease
    • Cancer

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Format
    • Liquid
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Buffer
    • PBS
    • Preservative
    • No preservatives
    • Stabilizer
    • No Stabilizers
    • Sterility
    • 0.2 μM filtered
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • The selection and application methods of this antibody provide new approaches for detecting and functionally studying endothelial cell surface antigens, and may have potential applications in transplantation, immunology, and tumor therapy.

    Target

    • Alternative Names
    • Melanoma Cell Adhesion Molecule; S-Endo 1 Endothelial-Associated Antigen; Melanoma-Associated Antigen MUC18; Cell Surface Glycoprotein P1H12; Melanoma-Associated Antigen A32; Gicerin
    • Cellular Localization
    • Membrane
    • Function
    • Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

    Recommended Products

    Secondary Antibody

    Isotype Control

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

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    Human Antibody Products Mouse Antibody Products Chimeric Antibody Products Humanized Antibody Products Rabbit Monoclonal Antibody Products Fab Antibody Products IgG Antibody Products ScFv Antibody Products Antibody Magnetic Beads ScFv-Fc Chimera Products Extracellular Vesicle (EV) Antibody Products
    CAT Product Name Application Type
    TAB-516CL Anti-Human MCAM Recombinant Antibody (ABX-MA1) WB, FuncS Antibody

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