Mouse Anti-MERTK scFv-Fc Chimera (VS-0325-FY31) (CAT#: VS-0325-FY31)

• Host Species
• Mouse

• Type
• Mouse IgG1, scFv-Fc

• Specificity
• Human MERTK

• Species Reactivity
• Human

• Applications
• Inhibition

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Alternative Names
• MER Proto-Oncogene, Tyrosine Kinase; C-Mer Proto-Oncogene Tyrosine Kinase; Receptor Tyrosine Kinase MerTK; Proto-Oncogene C-Mer; EC 2.7.10.1; MER; MER Receptor Tyrosine Kinase; Tyrosine-Protein Kinase Mer

• Gene ID
• 10461

• UniProt ID
• Q12866

• Long Name
• MER Proto-Oncogene, Tyrosine Kinase

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.

• Cellular Localization
• Cell membrane; Membrane

• Post Translation Modifications
• Autophosphorylated on Tyr-749, Tyr-753 and Tyr-754 in the activation loop allowing full activity. Autophosphorylated on Tyr-872 leading to recruitment of downstream partners of the signaling cascade such as PLCG2 (By similarity).

• Protein Refseq
• NP_006334.2

• Function
• Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment (PubMed:32640697).
  Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

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