Mouse Anti-MERTK scFv-Fc Chimera (VS-0325-FY31)
CAT#: VS-0325-FY31
The anti-MERTK scFv-Fc antibody targets MER receptor tyrosine kinase (MERTK), which is involved in phagocytosis, cell survival, and immune regulation. It is useful for studying the role of MERTK in tissue repair, inflammation, and cancer biology.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75622/1740_F11_62_selected.jpg
Normal Tissue
Figure 2 Adrenal gland
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36196/75498_B_6_5.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36196/75498_A_9_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36196/75498_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36196/75498_A_4_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (CACO-2, Hep G2, HUVEC TERT2, RT4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000153208-MERTK
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human MERTK
- Species Reactivity
- Human
- Applications
- Inhibition
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- MER Proto-Oncogene, Tyrosine Kinase; C-Mer Proto-Oncogene Tyrosine Kinase; Receptor Tyrosine Kinase MerTK; Proto-Oncogene C-Mer; EC 2.7.10.1; MER; MER Receptor Tyrosine Kinase; Tyrosine-Protein Kinase Mer
- Gene ID
- 10461
- UniProt ID
- Q12866
- Long Name
- MER Proto-Oncogene, Tyrosine Kinase
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
- Cellular Localization
- Cell membrane; Membrane
- Post Translation Modifications
- Autophosphorylated on Tyr-749, Tyr-753 and Tyr-754 in the activation loop allowing full activity. Autophosphorylated on Tyr-872 leading to recruitment of downstream partners of the signaling cascade such as PLCG2 (By similarity).
- Protein Refseq
- NP_006334.2
- Function
- Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment (PubMed:32640697).
Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
See other products for "MERTK"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1725CQ | Recombinant Mouse Anti-MERTK Antibody (NEUT-1725CQ) | BL, WB, IP, IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2214 | Hi-Affi™ Recombinant Rabbit Anti-MERTK Monoclonal Antibody (DS2214AB) | WB, IHC, IP, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0215-CN | Mouse Anti-MERTK Recombinant Antibody (HPAB-0215-CN) | WB, ELISA | Mouse IgG |
| HPAB-0216-CN | Mouse Anti-MERTK Recombinant Antibody (HPAB-0216-CN) | WB, ELISA | Mouse IgG |
| ZG-0138U | Human Anti-MERTK Recombinant Antibody (clone 8H11) | ELISA | Humanized IgG4 |
| VS3-XY1063 | Mouse Anti-MERTK Recombinant Antibody (clone 7E5G1) | ELISA, WB | Mouse IgG1 |
| VS3-WK909 | Rabbit Anti-MERTK Recombinant Antibody (VS3-WK909) | WB, IHC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0215-CN-S(P) | Mouse Anti-MERTK Recombinant Antibody; scFv Fragment (HPAB-0215-CN-S(P)) | WB, ELISA | Mouse scFv |
| HPAB-0216-CN-S(P) | Mouse Anti-MERTK Recombinant Antibody; scFv Fragment (HPAB-0216-CN-S(P)) | WB, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0215-CN-F(E) | Mouse Anti-MERTK Recombinant Antibody; Fab Fragment (HPAB-0215-CN-F(E)) | WB, ELISA | Mouse Fab |
| HPAB-0216-CN-F(E) | Mouse Anti-MERTK Recombinant Antibody; Fab Fragment (HPAB-0216-CN-F(E)) | WB, ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC607 | Recombinant Anti-MERTK Vesicular Antibody, EV Displayed (VS-0425-YC607) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4354 | Anti-Mouse MERTK Immunohistochemistry Kit | IHC |
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