Mouse Anti-TGFB2 (clone 6A5) scFv-Fc Chimera
CAT#: VS-0425-FY188
The anti-TGFB2 scFv-FC is a monoclonal antibody designed to target the Transforming Growth Factor Beta 2 (TGFB2) protein. The scFv-FC format combines a single-chain variable fragment (scFv) that specifically binds to TGFB2 with the human Fc domain, enhancing its stability, half-life, and potential for therapeutic applications. This antibody can be used for research, diagnostic, and therapeutic purposes, particularly in the fields of oncology, fibrosis, and wound healing.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line EFO-21
Immunofluorescent staining of human cell line EFO-21 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6134/2063_C8_2_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (EFO-21, hTERT-RPE1, U-2 OS)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000092969-TGFB2
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Specifications
- Immunogen
- Purified human TGFβ2 as an immunogen.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human TGFB2
- Species Reactivity
- Human
- Clone
- 6A5
- Applications
- Neutralization, ELISA
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Transforming Growth Factor Beta 2; Glioblastoma-Derived T-Cell Suppressor Factor; Prepro-Transforming Growth Factor Beta-2; BSC-1 Cell Growth Inhibitor; Polyergin; Cetermin; G-TSF
- Gene ID
- 7042
- UniProt ID
- P61812
- Long Name
- Transforming Growth Factor Beta 2
- Sequence Similarities
- Belongs to the TGF-beta family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- [Transforming growth factor beta-2 proprotein]: The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-2 (TGF-beta-2) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-2 inactive.
Glycosylation at Asn72, Asn140, and Asn241
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect TGFB2_HUMAN (1836)
Glycosylation from GlyGen 4 sites, 6 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001129071.1; NP_003229.1
- Function
- [Transforming growth factor beta-2 proprotein]: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. TGFB2_HUMAN,P61812
[Latency-associated peptide]: Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix.
Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2.
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Related Diseases
Inflammatory Bowel Diseases
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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