Necrosome Antibody Panel (MLKL, RIPK1, RIPK3)
CAT#: VS-0725-YC31
The Necrosome Antibody Panel are sets of 3 antibodies, specifically designed for the simultaneous detection of key proteins within the necrosome complex. Included in this essential set are antibodies against MLKL, RIPK1, and RIPK3. This panel provides a powerful and streamlined tool for investigating necroptosis and its role in various pathologies, consistently delivering robust and reproducible data for your mechanistic studies.
| Sub Cat | Component Name | Clone | Type | Target | Species Reactivity | Applications | |
| VS3-XY3429 | Rabbit Anti-MLKL Recombinant Antibody (clone R05-3H2) | R05-3H2 | Rabbit IgG | MLKL | Human, Mouse | WB, IHC-P | |
| VS3-FY1269 | Recombinant Rabbit Anti-RIPK1 Antibody (clone R08-9K5) | R08-9K5 | Rabbit IgG | RIPK1 | Human | Western Blot | |
| VS3-WK1228 | Mouse Anti-RIPK3 Recombinant Antibody (VS3-WK1228) | Mouse IgG1, κ | RIPK3 | Human | WB |
More Infomation
Specifications
- Targets
- MLKL, RIPK1, RIPK3
- Species Reactivity
- Human
- Research Area
- Necrosome
- Introduction
- The necrosome is a critical, multi-protein signaling complex that serves as the central platform for initiating and executing necroptosis, a highly inflammatory form of programmed cell death. Unlike apoptosis, which is typically immunologically silent, necroptosis is characterized by cellular swelling, permeabilization of the plasma membrane, and the release of intracellular contents, including various danger-associated molecular patterns (DAMPs) and pro-inflammatory cytokines. This lytic cell death mechanism actively fuels inflammation and contributes to host defense against certain pathogens, but also plays a significant role in various inflammatory and degenerative diseases.
- Storage
- Store at 4°C for up to a week. For long-term storage, store at -20°C or below.
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