Recombinant Rabbit Anti-ABCB1 Antibody (clone R02-6B2) (CAT#: VS3-FY5)
This product is a recombinant rabbit antibody that recognizes human ABCB1 protein. It can detect a band of approximately 141 kDa (observedd molecular weight: 130-180 kDa).
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WB
Figure 1. Recombinant Rabbit Anti-ABCB1 Antibody (clone R02-6B2) in WB.
Western blot analysis of P-glycoprotein from HeLa lysates using P-glycoprotein antibody.
Specifications
- Immunogen
- Recombinant protein of human P Glycoprotein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human ABCB1
- Species Reactivity
- Human
- Clone
- R02-6B2
- Applications
- Western Blot
- Conjugate
- Unconjugated
- MW
- Calculated MW: 141 kDa; Observed MW: 130-180 kDa
Product Property
- Purification
- Affinity Purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% Glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- ATP Binding Cassette Subfamily B Member 1; ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1; Multidrug Resistance Protein 1; Colchicin Sensitivity; P-Glycoprotein 1; EC 3.6.3.44; MDR1; PGY1; ATP-Binding Cassette Sub-Family B Member 1; Doxorubicin Resistance
- Gene ID
- 5243
- UniProt ID
- P08183
- Sequence Similarities
- Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
- Cellular Localization
- Cell membrane, Membrane
- Protein Refseq
- NP_000918.2
- Function
- Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218).
Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203).
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218).
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "ABCB1"
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-22-F(E) | Recombinant Anti-human ABCB1 Antibody Fab Fragment | FC, WB, FuncS | Fab |
| MHH-22-F(E) | Recombinant Human Anti-human ABCB1 Antibody Fab Fragment | WB, FC, FuncS | Fab |
| PFBC-052 | Mouse Anti-ABCB1 Recombinant Antibody (clone C219); Fab Fragment | WB, Neut, IF, IHC, IHC-P, IP | Mouse IgG |
| PFBC-444 | Human Anti-ABCB1 Recombinant Antibody Fab Fragment (PFBC-444) | FC, Block, IP, IHC | Human Fab |
| HPAB-M0001-YC-F(E) | Mouse Anti-ABCB1 Recombinant Antibody (clone 6C6); Fab Fragment | IHC | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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