Recombinant Anti-ACVRL1 Vesicular Antibody, EV Displayed (VS-0425-YC491)
CAT#: VS-0425-YC491
The Recombinant Anti-ACVRL1 Vesicular Antibody, EV Displayed (VS-0425-YC491) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ACVRL1-expressed cells or tissues. ACVRL1 is a TGF-beta receptor featuring kinase domain elements and is implicated in Rendu-Osler-Weber syndrome. ACVRL1 is a critical participant in receptor signaling pathways.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows strong granular cytoplasmic positivity in neuronal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_7_3.jpg
Normal Tissue
Figure 4 Gallbladder
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_5_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Elongated or late spermatids Staining: High Intensity: Strong Quantity:>75% Leydig cells Staining: Low Intensity: Weak Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, EFO-21, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139567-ACVRL1
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ACVRL1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Cynomolgus
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Activin A receptor like type 1
- Biological Process
- Angiogenesis
- Molecular Function
- Kinase, Receptor, Serine/threonine-protein kinase, Transferase
- Introduction
- This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
- Alternative Names
- ACVRLK1, ALK1, HHT, HHT2, ORW2
- Gene ID
- 94
- UniProt ID
- P37023
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| HPAB-0136-CN-S(P) | Human Anti-ACVRL1 Recombinant Antibody (clone MOR05444); scFv Fragment | ELISA, IHC | Human scFv |
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| HPAB-J0025-YC-S(P) | Human Anti-ACVRL1 Recombinant Antibody; scFv Fragment (HPAB-J0025-YC-S(P)) | ELISA, FC, WB | Human scFv |
| HPAB-J0026-YC-S(P) | Human Anti-ACVRL1 Recombinant Antibody; scFv Fragment (HPAB-J0026-YC-S(P)) | ELISA, FC, WB, Inhib, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0136-CN-F(E) | Human Anti-ACVRL1 Recombinant Antibody (clone MOR05444); Fab Fragment | ELISA, IHC | Human Fab |
| HPAB-0137-CN-F(E) | Human Anti-ACVRL1 Recombinant Antibody (clone MOR05377); Fab Fragment | ELISA, IHC | Human Fab |
| HPAB-J0024-YC-F(E) | Human Anti-ACVRL1 Recombinant Antibody; Fab Fragment (HPAB-J0024-YC-F(E)) | ELISA, FC, WB | Human Fab |
| HPAB-J0025-YC-F(E) | Human Anti-ACVRL1 Recombinant Antibody; Fab Fragment (HPAB-J0025-YC-F(E)) | ELISA, FC, WB | Human Fab |
| HPAB-J0026-YC-F(E) | Human Anti-ACVRL1 Recombinant Antibody; Fab Fragment (HPAB-J0026-YC-F(E)) | ELISA, FC, WB, Inhib, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-003ML | Afuco™ Anti-ACVRL1 ADCC Recombinant Antibody, ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0024-YC | Human Anti-ACVRL1 Recombinant Antibody (HPAB-J0024-YC) | ELISA, FC, WB | Human IgG1 |
| HPAB-J0025-YC | Human Anti-ACVRL1 Recombinant Antibody (HPAB-J0025-YC) | ELISA, FC, WB | Human IgG |
| HPAB-J0026-YC | Human Anti-ACVRL1 Recombinant Antibody (HPAB-J0026-YC) | ELISA, FC, WB, Inhib, FuncS | Human IgG1 |
| HPAB-J0027-YC | Human Anti-ACVRL1 Recombinant Antibody (HPAB-J0027-YC) | ELISA | Human IgG |
| HPAB-J0028-YC | Human Anti-ACVRL1 Recombinant Antibody (HPAB-J0028-YC) | ELISA, FC, WB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1261 | AbPlus™ Anti-ACVRL1 Magnetic Beads (VS-0724-YC1261) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY91 | Human Anti-ACVRL1 (clone MOR05377) scFv-Fc Chimera | ELISA, IHC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY141 | Anti-ACVRL1 Immunohistochemistry Kit | IHC |
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