Recombinant Anti-ALCAM Vesicular Antibody, EV Displayed (VS-0425-YC532)
CAT#: VS-0425-YC532
The Recombinant Anti-ALCAM Vesicular Antibody, EV Displayed (VS-0425-YC532) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ALCAM-expressed cells or tissues. ALCAM is an activated leukocyte cell adhesion molecule, also known as CD166. Implicated in cell adhesion and migration, it interacts with T-cell antigen CD6.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10926/52_B2_2_selected.jpg
Normal Tissue
Figure 2 Parathyroid gland
High expression in parathyroid gland
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10926/26851_A_1_8_val_selected.jpg
Normal Tissue
Figure 3 Kidney
Bowman's capsule Staining: High Intensity: Strong Quantity:>75% Collecting ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10926/26851_A_7_5.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10926/26851_B_7_5.jpg
Normal Tissue
Figure 5 Stomach
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10926/26851_A_6_1.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10926/26851_A_9_3.jpg
Normal Tissue
Figure 7 Liver
Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10926/26851_A_9_4.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (hTERT-HME1, U-138 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000170017-ALCAM
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ALCAM
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Activated leukocyte cell adhesion molecule
- Biological Process
- Adaptive immunity, Cell adhesion, Immunity
- Cellular Localization
- Vesicles
- Introduction
- This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]
- Alternative Names
- CD166, MEMD
- Gene ID
- 214
- UniProt ID
- Q13740
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "ALCAM"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-031CL | Human Anti-ALCAM Recombinant Antibody (TAB-031CL) | ELISA | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-019CQ | Mouse Anti-ALCAM Recombinant Antibody (clone CBL314) | WB, Block | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0134 | Hi-Affi™ Rabbit Anti-ALCAM Recombinant Antibody (clone DS134AB) | WB, IHC, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FN-021CQ | Mouse Anti-ALCAM Recombinant Antibody (clone 3A6) | FC, Block | Mouse IgG1 |
| MOR-0012-FY | Mouse Anti-ALCAM Recombinant Antibody (clone AZN-L50) | FC, FuncS, IF, IP, WB | Mouse IgG2a |
| ZG-0372F | Mouse Anti-ALCAM Recombinant Antibody (ZG-0372F) | IHC, ELISA | Mouse IgG |
| ZG-0373F | Mouse Anti-ALCAM Recombinant Antibody (ZG-0373F) | WB, ELISA | Mouse IgG |
| VS7-HM75 | Mouse Anti-ALCAM Recombinant Antibody (clone CBL030HM) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0273 | APC-H-2Kd/Human CD166 (SLNVSAISI) MHC Tetramer | FCM | |
| MHC-CN0274 | PE-H-2Kd/Human CD166 (SLNVSAISI) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0951-FY-F(E) | Human Anti-ALCAM Recombinant Antibody; Fab Fragment (HPAB-0951-FY-F(E)) | IHC | Human Fab |
| HPAB-0952-FY-F(E) | Human Anti-ALCAM Recombinant Antibody; Fab Fragment (HPAB-0952-FY-F(E)) | IHC | Human Fab |
| HPAB-0953-FY-F(E) | Human Anti-ALCAM Recombinant Antibody; Fab Fragment (HPAB-0953-FY-F(E)) | IHC | Human Fab |
| HPAB-0954-FY-F(E) | Human Anti-ALCAM Recombinant Antibody; Fab Fragment (HPAB-0954-FY-F(E)) | IHC | Human Fab |
| HPAB-0955-FY-F(E) | Human Anti-ALCAM Recombinant Antibody; Fab Fragment (HPAB-0955-FY-F(E)) | IHC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0951-FY-S(P) | Human Anti-ALCAM Recombinant Antibody; scFv Fragment (HPAB-0951-FY-S(P)) | IHC | Human scFv |
| HPAB-0952-FY-S(P) | Human Anti-ALCAM Recombinant Antibody; scFv Fragment (HPAB-0952-FY-S(P)) | IHC | Human scFv |
| HPAB-0953-FY-S(P) | Human Anti-ALCAM Recombinant Antibody; scFv Fragment (HPAB-0953-FY-S(P)) | IHC | Human scFv |
| HPAB-0954-FY-S(P) | Human Anti-ALCAM Recombinant Antibody; scFv Fragment (HPAB-0954-FY-S(P)) | IHC | Human scFv |
| HPAB-0955-FY-S(P) | Human Anti-ALCAM Recombinant Antibody; scFv Fragment (HPAB-0955-FY-S(P)) | IHC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC794 | AbPlus™ Anti-Alcam Magnetic Beads (VS-0724-YC794) | IP, Protein Purification | |
| VS-0724-YC999 | AbPlus™ Anti-ALCAM Magnetic Beads (VS-0724-YC999) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC19 | Rabbit Anti-ALCAM Antibody (VS-0924-YC19) - Cancer Stem Cell Marker | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY289 | Anti-ALCAM Immunohistochemistry Kit | IHC | |
| VS-0525-XY290 | Anti-Mouse ALCAM Immunohistochemistry Kit | IHC |
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