Recombinant Anti-APLNR Vesicular Antibody, EV Displayed (VS-0425-YC419)
CAT#: VS-0425-YC419
The Recombinant Anti-APLNR Vesicular Antibody, EV Displayed (VS-0425-YC419) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to APLNR-expressed cells or tissues. The APLNR is a GPCR regulating cardiovascular functions and acts as a coreceptor for HIV-1.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25842/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25842/57343_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25842/57343_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25842/57343_A_8_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25842/57343_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25842/57343_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (AF22, HEL, K-562, NTERA-2, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134817-APLNR
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Recombinant Antibody
- Application
- Antagonist, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- APLNR
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Apelin receptor
- Biological Process
- Angiogenesis, Gastrulation, Host-virus interaction
- Molecular Function
- Developmental protein, G-protein coupled receptor, Receptor, Transducer
- Introduction
- This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]
- Alternative Names
- AGTRL1, APJ, APJR, FLJ90771
- Gene ID
- 187
- UniProt ID
- P35414
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "APLNR"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0929CLV-F(E) | Mouse Anti-APLNR Recombinant Antibody (TAB-0929CLV-F(E)); Fab Fragment | ELISA | Mouse Fab |
| TAB-0930CLV-F(E) | Human Anti-APLNR Recombinant Antibody; Fab Fragment (TAB-0930CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| TAB-0931CLV-F(E) | Human Anti-APLNR Recombinant Antibody; Fab Fragment (TAB-0931CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| TAB-0929CLV-S(P) | Mouse Anti-APLNR Recombinant Antibody (TAB-0929CLV-S(P)); scFv Fragment | ELISA | Mouse scFv |
| TAB-0930CLV-S(P) | Mouse Anti-APLNR Recombinant Antibody; scFv Fragment (TAB-0930CLV-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0932CLV-F(E) | Human Anti-APLNR Recombinant Antibody (TAB-0932CLV-F(E)); Fab Fragment | ELISA | Human Fab |
| TAB-0933CLV-F(E) | Human Anti-APLNR Recombinant Antibody (TAB-0933CLV-F(E)); Fab Fragment | ELISA | Human Fab |
| TAB-0934CLV-F(E) | Human Anti-APLNR Recombinant Antibody (TAB-0934CLV-F(E)); Fab Fragment | ELISA | Human Fab |
| TAB-0935CLV-F(E) | Human Anti-APLNR Recombinant Antibody (TAB-0935CLV-F(E)); Fab Fragment | ELISA | Human Fab |
| TAB-0936CLV-F(E) | Human Anti-APLNR Recombinant Antibody (TAB-0936CLV-F(E)); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABJ-0007 | Camelid Anti-APLNR Recombinant Antibody (PABJ-0007) | ELISA, Antagonist | Camelid VHH |
| PABJ-0008 | Camelid Anti-APLNR Recombinant Antibody (PABJ-0008) | ELISA, Agonist | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC642 | AbPlus™ Anti-APLNR Magnetic Beads (VS-0724-YC642) | IP, Protein Purification |
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