Mouse Anti-APP Recombinant Antibody (clone 5E3) (CAT#: HPAB-0104-YJ)

Figure 1 The results of Biacore™ sensorgram overlays which shows the binding of BSA-conjugated linear or comprising the SNK epitope to linear (3F5, 3G2), cyclic (5E3, 5D8) and intermediate-specific (4D11, 4D12) monoclonal antibodies, and reactivity of these antibodies to synthetic Αβ 1-42 oligomers.

Figure 2 Results of static light scatter experiments to test Αβ polymerization in the presence ("5E3") or absence ("C") of antibody 5E3.

Figure 3 The results of a neuronal toxicity analysis which shows the degree of cell survival for cells incubated with a mock control, soluble monomeric and oligomeric Αβ 1 -40 in the presence and absence of 5E3 antibody at different concentrations.

Figure 4 Flow cytometry trace which shows the comparison of cells binding labelled 5E3 antibody and a negative control to the APP located at the cell surface.

Figure 5 The results of Biacore™ analysis which shows the binding to synthetic Αβ 1-42 oligomers to cyclic monoclonal antibody 5E3 at varying concentrations.

Figure 6 The results of Biacore™ sensorgram overlays which shows the binding of BSA-conjugated linear or comprising the SNK epitope to linear (3F5, 3G2), cyclic (5E3, 5D8) and intermediate-specific (4D11, 4D12) monoclonal antibodies, and reactivity of these antibodies to synthetic Αβ 1-42 oligomers.