Recombinant Anti-BCL2L1 Vesicular Antibody, EV Displayed (VS-0425-YC20) (CAT#: VS-0425-YC20)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• BCL2L1

• Host Animal
• Rabbit

• Antibody Isotype
• IgG

• Species Reactivity
• Human

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• Protein A

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• BCL2 like 1

• Biological Process
• Apoptosis, Endocytosis

• Cellular Localization
• Mitochondria, Nucleoli fibrillar center, Acrosome

• Introduction
• The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.

• Alternative Names
• Bcl-X, bcl-xL, bcl-xS, BCL2L, BCLX, PPP1R52

• Gene ID
• 598

• UniProt ID
• Q07817

Select a product category from the dropdown menu below to view related products.