Recombinant Anti-BTN3A1 Vesicular Antibody, EV Displayed (VS-0425-YC254)
CAT#: VS-0425-YC254
The Recombinant Anti-BTN3A1 Vesicular Antibody, EV Displayed (VS-0425-YC254) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to BTN3A1-expressed cells or tissues. The BTN3A1 is a protein with immunoglobulin domains, associated with the major histocompatibility complex.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12565/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human kidney
Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in a granular pattern in renal tubules.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12565/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12565/40150_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12565/40150_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12565/40150_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12565/40150_A_9_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12565/40150_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12565/40150_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000026950-BTN3A1
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- BTN3A1
- Host Animal
- Mouse
- Antibody Isotype
- IgG1
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein G
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Butyrophilin subfamily 3 member A1
- Biological Process
- Adaptive immunity, Immunity
- Cellular Localization
- Vesicles
- Introduction
- The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]
- Alternative Names
- BT3.1, BTF5, BTN3.1, CD277
- Gene ID
- 11119
- UniProt ID
- O00481
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-127-F(E) | Recombinant Anti-human BTN3A1 Antibody Fab Fragment | Neut, WB, FuncS | Fab |
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| PFBL-411 | Mouse Anti-BTN3A1 Recombinant Antibody (clone 20.1); Fab Fragment | FC, Block | Mouse Fab |
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| CAT | Product Name | Application | Type |
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| MOB-127-S(P) | Recombinant Anti-human BTN3A1 Antibody scFv Fragment | FC, IP, FuncS | scFv |
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| PSBL-411 | Mouse Anti-BTN3A1 Recombinant Antibody (clone 20.1); scFv Fragment | FC, Block | Mouse scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1312CL | Mouse Anti-BTN3A1 Recombinant Antibody (TAB-1312CL) | FC, FuncS | Mouse IgG |
| TAB-1313CL | Mouse Anti-BTN3A1 Recombinant Antibody (TAB-1313CL) | FC | Mouse IgG |
| TAB-1314CL | Mouse Anti-BTN3A1 Recombinant Antibody (TAB-1314CL) | ELISA, FC | Mouse IgG |
| TAB-1312CL-S(P) | Mouse Anti-BTN3A1 Recombinant Antibody; scFv Fragment (TAB-1312CL-S(P)) | FC, FuncS | Mouse scFv |
| TAB-1313CL-S(P) | Mouse Anti-BTN3A1 Recombinant Antibody; scFv Fragment (TAB-1313CL-S(P)) | FC | Mouse scFv |
| CAT | Product Name | Application | Type |
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| VS-0225-XY7 | CytoStream™ Mouse Anti-BTN3A1 Recombinant Antibody (clone 232-5) | FC | Mouse IgG2a, kappa |
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