Recombinant Anti-CCR6 Vesicular Antibody, EV Displayed (VS-0425-YC641)
CAT#: VS-0425-YC641
The Recombinant Anti-CCR6 Vesicular Antibody, EV Displayed (VS-0425-YC641) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CCR6-expressed cells or tissues. CCR6 is a chemokine receptor, involved in immune response regulation, related to diseases like scleroderma.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6820/17235_B_8_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6820/17235_A_9_3.jpg
Normal Tissue
Figure 3 Liver
Cholangiocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6820/17235_A_8_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6820/17235_A_8_5.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6820/17235_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (Hep G2, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000112486-CCR6
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CCR6
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Cynomolgus
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- C-C motif chemokine receptor 6
- Molecular Function
- G-protein coupled receptor, Receptor, Transducer
- Introduction
- CCR6 (C-C Motif Chemokine Receptor 6) is a Protein Coding gene. Diseases associated with CCR6 include Limited Scleroderma and Diffuse Cutaneous Systemic Sclerosis. Among its related pathways are Defensins and Akt Signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR7.
- Alternative Names
- BN-1, CD196, CKR-L3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, STRL22
- Gene ID
- 1235
- UniProt ID
- P51684
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Datasheet
MSDS
COA
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| HPAB-0084-CN-S(P) | Human Anti-CCR6 Recombinant Antibody; scFv Fragment (HPAB-0084-CN-S(P)) | Neut, ELISA, FC | Humanized scFv |
| HPAB-0085-CN-S(P) | Human Anti-CCR6 Recombinant Antibody; scFv Fragment (HPAB-0085-CN-S(P)) | Neut, ELISA, FC | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-160 | Recombinant Human Anti-human CCR6 Antibody | WB, RIA, FuncS | IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1543CL | Anti-Human CCR6 Recombinant Antibody (MSM-R605) | FC | Fully human antibody |
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| TAB-1543CL-S(P) | Anti-Human CCR6 Recombinant Antibody scFv Fragment (MSM-R605) | FC | Fully human antibody |
| TAB-1544CL-S(P) | Anti-Human CCR6 Recombinant Antibody scFv Fragment (MSM-R606) | FC | Fully human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY12 | CytoStream™ Rat Anti-CCR6 Recombinant Antibody (clone 140706) | FC | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1103 | Anti-CCR6 Immunohistochemistry Kit | IHC |
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