Recombinant Anti-CD8A Vesicular Antibody, EV Displayed (VS-0425-YC377)
CAT#: VS-0425-YC377
The Recombinant Anti-CD8A Vesicular Antibody, EV Displayed (VS-0425-YC377) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CD8A-expressed cells or tissues. The CD8A is a protein involved in T cell differentiation and viral defense, expressed across various bodily structures.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37756/1373_A3_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37756/1492_D3_2_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37756/1377_A3_1_blue_red_green.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12/97_A_7_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000153563-CD8A
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CD8A
- Host Animal
- Rat
- Antibody Isotype
- IgG
- Species Reactivity
- Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- CD8a molecule
- Biological Process
- Adaptive immunity, Immunity
- Cellular Localization
- Plasma membrane
- Introduction
- Enables identical protein binding activity. Acts upstream of or within several processes, including cytotoxic T cell differentiation; defense response to virus; and positive regulation of calcium-mediated signaling. Located in external side of plasma membrane. Part of receptor complex. Is expressed in several structures, including endocrine gland; exocrine gland; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in primary immunodeficiency disease.
- Alternative Names
- Ly-2; Ly-B; Ly-35; Lyt-2
- Gene ID
- 12525
- UniProt ID
- P01731
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Datasheet
MSDS
COA
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| HPAB-0189-CN-S(P) | Mouse Anti-CD8A Recombinant Antibody; scFv Fragment (HPAB-0189-CN-S(P)) | FC | Mouse scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-144 | Rat Anti-CD8A Recombinant Antibody (clone YTS 105.18); scFv Fragment | Neut | Rat scFv |
| HPAB-0188-CN-F(E) | Mouse Anti-CD8A Recombinant Antibody; Fab Fragment (HPAB-0188-CN-F(E)) | FC | Mouse Fab |
| HPAB-0189-CN-F(E) | Mouse Anti-CD8A Recombinant Antibody; Fab Fragment (HPAB-0189-CN-F(E)) | FC | Mouse Fab |
| FAMAB-0009-CN-F(E) | Mouse Anti-CD8A Recombinant Antibody (clone CT8); Fab Fragment | FC | Mouse Fab |
| FAMAB-0010-CN-F(E) | Mouse Anti-CD8A Recombinant Antibody (clone EP72); Fab Fragment | FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-428CQ | Mouse Anti-CD8A Recombinant Antibody (clone UCHT4) | FC, IHC-Fr, IHC-P, IP, Separation, Block | Mouse IgG2a, κ |
| NEUT-431CQ | Rat Anti-CD8A Recombinant Antibody (clone 53-6.7) | ICC, IF, FC, IHC-Fr, IP, FuncS, Block | Rat IgG2a, κ |
| NEUT-432CQ | Rat Anti-CD8A Recombinant Antibody (clone MAB0811) | Block, Depletion | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-429CQ | Mouse Anti-CD8A Recombinant Antibody (clone CT-8) | Neut, FC, IHC, IHC-Fr, IHC-P, IP, ICC | Mouse IgG1, κ |
| NEUT-430CQ | Mouse Anti-CD8A Recombinant Antibody (clone LT8) | WB, Neut | Mouse IgG1 |
| NEUT-433CQ | Mouse Anti-CD8A Recombinant Antibody (clone 76-2-11) | Neut, FC, IHC-Fr, IHC-P, IP | Mouse IgG2a, κ |
| NEUT-434CQ | Mouse Anti-Cd8a Recombinant Antibody (clone OX-8) | WB, Neut, FC, IHC, IHC-Fr, IHC-P, IP, CyTOF® | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0582 | Hi-Affi™ Rabbit Anti-CD8A Recombinant Antibody (clone DS582AB) | IHC | Rabbit IgG |
| MOR-0589 | Hi-Affi™ Rabbit Anti-CD8A Recombinant Antibody (clone DS589AB) | IHC-P | Rabbit IgG |
| MOR-0590 | Hi-Affi™ Rabbit Anti-CD8A Recombinant Antibody (clone DS590AB), PE | FC | Rabbit IgG |
| MOR-0057-FY | Rabbit Anti-CD8A Recombinant Antibody (clone AFY0028) | ICC, IF, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0009-CN | Mouse Anti-CD8A Recombinant Antibody (clone CT8) | FC | Mouse IgG |
| FAMAB-0010-CN | Mouse Anti-CD8A Recombinant Antibody (clone EP72) | FC | Mouse IgG |
| FAMAB-0011-CN | Mouse Anti-CD8A Recombinant Antibody (clone 3-298) | FC | Mouse IgG |
| FAMAB-0037-CN | Mouse Anti-CD8A Recombinant Antibody (clone 6G5) | WB, IP, IF | Mouse IgG1 |
| FAMAB-0038-CN | Mouse Anti-CD8A Recombinant Antibody (clone 1C9) | WB, IP, IF | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0041-CN | Mouse Anti-CD8A Recombinant Antibody (clone 13C5) | WB, IP, IF | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY114 | Mouse Anti-NHP CD8A Recombinant Antibody (clone T8/209) | ELISA | Mouse IgG1, kappa |
| VS-1024-XY112 | Rat Anti-NHP CD8A Recombinant Antibody (clone YTC182.20) | FC | Rat IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY78 | CytoStream™ Mouse Anti-CD8A Recombinant Antibody (VS-0225-XY78) | FC | Mouse IgG2a, kappa |
| VS-0225-XY79 | CytoStream™ Mouse Anti-CD8A Recombinant Antibody (clone SK1) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY375 | Anti-CD8A Immunohistochemistry Kit | IHC | |
| VS-0525-XY1238 | Anti-Mouse CD8A Immunohistochemistry Kit | IHC | |
| VS-0525-XY1237 | Anti-Human CD8A Immunohistochemistry Kit | IHC | |
| VS-0525-XY1240 | Anti-Rat CD8A Immunohistochemistry Kit | IHC |
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