Recombinant Mouse Anti-CEACAM5 Antibody (clone 10D8-8G10-2A3)

Name: Recombinant Mouse Anti-CEACAM5 Antibody (clone 10D8-8G10-2A3)
SKU: VS3-FY368
Rating: 5 (1 reviews)

CAT#: VS3-FY368

This product is a recombinant mouse antibody that recognizes human CEACAM5 protein. The mAb was purified by affinity chromatography.

Gene Expression Tested Data

Subcellular Location Figure 1 IF staining of human cell line HaCaT

Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19758/1660_G5_2_selected.jpg

Subcellular Location Figure 2 IHC staining of human duodenum

Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in a subset of leukocytes.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11041/ihc_selected.jpg

Normal Tissue Figure 3 Colon

Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Gradient
Gradient: Ascending
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_7_3.jpg

Normal Tissue Figure 4 Rectum

Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_6_3.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enriched (OE19)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105388-CEACAM5

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IHC

Figure 1. Recombinant Mouse Anti-CEACAM5 Antibody (clone 10D8-8G10-2A3) in IHC.

Immunohistochemical analysis of paraffin-embedded tonsil using antibody to carcinoembryonic antigen CEA. High pressure and high temperature sodium citrate pH 6.0 for antigen retrieval.

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Specifications

Immunogen
Synthesized peptide derived from human carcinoembryonic antigen(CEA)

Host Species
Mouse

Type
Mouse IgG2b

Specificity
Human CEACAM5

Species Reactivity
Human

Clone
10D8-8G10-2A3

Applications
Immunohistochemistry-Paraffin

Conjugate
Unconjugated

Product Property

Purification
Affinity Chromatography Purified

Purity
>95%

Format
Liquid

Buffer
PBS pH 7.3, 50% Glycerol, 0.5% BSA

Preservative
0.02% Sodium azide

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

Application Notes
Immunohistochemistry: 1/100-1/500

Target

Alternative Names
Carcinoembryonic Antigen Related Cell Adhesion Molecule 5; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5; Meconium Antigen 100; CEA; Carcinoembryonic Antigen; CD66e Antigen; CD66e

Gene ID
1048

UniProt ID
P06731

Sequence Similarities
Belongs to the immunoglobulin superfamily. CEA family.

Cellular Localization
Cell membrane, Membrane

Post Translation Modifications
Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.

Protein Refseq
NP_001278413.1; NP_001295327.1; NP_004354.3

Function
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933).
Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308).
Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS3-FY368.pdf

MSDS

MSDS - VS3-FY368.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Secondary Antibody

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TAB-410LC-F(E)	Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-410LC-F(E))	ELISA	Humanized Fab
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CAT	Product Name	Application	Type
HPAB-0155-FY-S(P)	Mouse Anti-CEACAM5 Recombinant Antibody; scFv Fragment (HPAB-0155-FY-S(P))	Activ	Humanized scFv
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HPAB-0155-FY-F(E)	Mouse Anti-CEACAM5 Recombinant Antibody; Fab Fragment (HPAB-0155-FY-F(E))	Activ	Humanized Fab
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HPAB-1094WJ-F(E)	Mouse Anti-CEACAM5 Recombinant Antibody; Fab Fragment (HPAB-1094WJ-F(E))	ELISA, FC	Mouse Fab
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