Recombinant Anti-CFTR Vesicular Antibody, EV Displayed (VS-0425-YC395)
CAT#: VS-0425-YC395
The Recombinant Anti-CFTR Vesicular Antibody, EV Displayed (VS-0425-YC395) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CFTR-expressed cells or tissues. The CFTR is a chloride channel protein crucial for ion transport and epithelial function, with mutations causing cystic fibrosis.
Gene Expression
Normal Tissue
Figure 1 High expression in pancreas
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21939/169902_A_1_3_val_selected.jpg
Normal Tissue
Figure 2 Low expression in skeletal muscle.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1951/160344_B_3_6_val_selected.jpg
Normal Tissue
Figure 3 Low expression in lymph node
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21939/169902_A_9_8_val_selected.jpg
Normal Tissue
Figure 4 Pancreas
Exocrine glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21939/169902_A_1_3.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (CACO-2, MOLT-4, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000001626-CFTR
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CFTR
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- CF transmembrane conductance regulator
- Biological Process
- Ion transport, Transport
- Molecular Function
- Chloride channel, Ion channel, Isomerase
- Introduction
- This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome.
- Alternative Names
- ABC35, ABCC7, CF, CFTR/MRP, dJ760C5.1, MRP7, TNR-CFTR
- Gene ID
- 1080
- UniProt ID
- P13569
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "CFTR"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1704z | Mouse Anti-CFTR Recombinant Antibody (clone 28C12) | WB, IF, IHC | Mouse IgG1 |
| MOB-0481CT | Recombinant Mouse anti-Human CFTR Monoclonal antibody (N4B8) | FC, IHC-Fr, IHC-P | |
| MRO-1772-CN | Rabbit Anti-CFTR Polyclonal Antibody (MRO-1772-CN) | WB, IF, IHC, FC | Rabbit IgG |
| PABS-0273 | Camelid Anti-CFTR Recombinant Antibody (PABS-0273) | Thermal shift assay (DSF), Isothermal titration microcalorimertry (ITC), Differential scanning calorimetry (DSC), FC, pull-down, ELISA, FuncS | Camelid VHH |
| PABS-0274 | Camelid Anti-CFTR Recombinant Antibody (clone G3a) | Thermal shift assay (DSF), Isothermal titration microcalorimertry (ITC), Differential scanning calorimetry (DSC), FC, Pull-down, ELISA, FuncS | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-458CQ | Mouse Anti-CFTR Recombinant Antibody (clone CF3) | Block, FC, ICC, IF, IHC, IHC-P, IP, WB | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NBD-0019-YJ-VHH | Camelid Anti-CFTR Recombinant Single Domain Antibody (NBD-0019-YJ-VHH) | ELISA, Thermal stabilization | Camelid VHH |
| NBD-0020-YJ-VHH | Camelid Anti-CFTR Recombinant Single Domain Antibody (NBD-0020-YJ-VHH) | ELISA | Camelid VHH |
| NBD-0021-YJ-VHH | Camelid Anti-CFTR Recombinant Single Domain Antibody (NBD-0021-YJ-VHH) | ELISA, Thermal stabilization | Camelid VHH |
| NBD-0022-YJ-VHH | Camelid Anti-CFTR Recombinant Single Domain Antibody (NBD-0022-YJ-VHH) | ELISA, Thermal stabilization | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY436 | Anti-CFTR Immunohistochemistry Kit | IHC | |
| VS-0525-XY1406 | Anti-Mouse CFTR Immunohistochemistry Kit | IHC | |
| VS-0525-XY1405 | Anti-Human CFTR Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC32 | Recombinant Anti-CFTR Biparatopic Antibody, Tandem scFv | ELISA, FC, Pull-down | Tandem sdAb |
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