Recombinant Anti-CLEC14A Vesicular Antibody, EV Displayed (VS-0425-YC125)
CAT#: VS-0425-YC125
The Recombinant Anti-CLEC14A Vesicular Antibody, EV Displayed (VS-0425-YC125) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CLEC14A-expressed cells or tissues. The CLEC14A is a protein that is a member of the C-type lectin/C-type lectin-like domain superfamily, involved in diverse functions such as cell adhesion and signaling. It plays a role in angiogenesis and is more expressed in tumor endothelium than normal tissues, serving as a candidate for tumor vascular targeting.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HUVEC TERT2
Immunofluorescent staining of human cell line HUVEC TERT2 shows localization to endoplasmic reticulum & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39468/1752_E8_8_cr5804e685b5256_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows distinct positivity in endothelial cells as well as glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39468/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39468/86459_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39468/86459_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39468/86459_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39468/86459_A_5_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (fHDF/TERT166, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000176435-CLEC14A
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CLEC14A
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- C-type lectin domain containing 14A
- Cellular Localization
- Endoplasmic reticulum, Golgi apparatus
- Introduction
- This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting.
- Alternative Names
- C14orf27
- Gene ID
- 161198
- UniProt ID
- Q86T13
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Datasheet
MSDS
COA
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See other products for "CLEC14A"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-626-sdAb | Recombinant Anti-Human CLEC14A VHH Single Domain Antibody | IP, FC, ChiP, Neut | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-528LC | Human Anti-CLEC14A Recombinant Antibody (TAB-528LC) | ICC, ELISA, FC | Human IgG1 |
| TAB-529LC | Human Anti-CLEC14A Recombinant Antibody (TAB-529LC) | ICC, ELISA, FC | Human IgG1 |
| TAB-530LC | Human Anti-CLEC14A Recombinant Antibody (TAB-530LC) | ICC, ELISA, FC | Human IgG1 |
| TAB-531LC | Human Anti-CLEC14A Recombinant Antibody (TAB-531LC) | ICC, ELISA, FC | Human IgG1 |
| TAB-528LC-S(P) | Human Anti-CLEC14A Recombinant Antibody; scFv Fragment (TAB-528LC-S(P)) | ICC, ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4090 | Hi-Affi™ Rabbit Anti-CLEC14A Recombinant Antibody (clone SI157DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0049-YC | Human Anti-CLEC14A Recombinant Antibody (HPAB-N0049-YC) | FC, ELISA, FuncS | Human IgG1 |
| HPAB-AP292-YC | Human Anti-CLEC14A Recombinant Antibody (HPAB-AP292-YC) | ELISA, Block | Human IgG |
| HPAB-AP293-YC | Human Anti-CLEC14A Recombinant Antibody (HPAB-AP293-YC) | ELISA, Block | Human IgG |
| HPAB-AP294-YC | Human Anti-CLEC14A Recombinant Antibody (HPAB-AP294-YC) | ELISA | Human IgG |
| HPAB-AP295-YC | Human Anti-CLEC14A Recombinant Antibody (HPAB-AP295-YC) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0049-YC-F(E) | Human Anti-CLEC14A Recombinant Antibody; Fab Fragment (HPAB-N0049-YC-F(E)) | FC, ELISA, FuncS | Human Fab |
| HPAB-AP292-YC-F(E) | Human Anti-CLEC14A Recombinant Antibody; Fab Fragment (HPAB-AP292-YC-F(E)) | ELISA, Block | Human Fab |
| HPAB-AP293-YC-F(E) | Human Anti-CLEC14A Recombinant Antibody; Fab Fragment (HPAB-AP293-YC-F(E)) | ELISA, Block | Human Fab |
| HPAB-AP294-YC-F(E) | Human Anti-CLEC14A Recombinant Antibody; Fab Fragment (HPAB-AP294-YC-F(E)) | ELISA | Human Fab |
| HPAB-AP295-YC-F(E) | Human Anti-CLEC14A Recombinant Antibody; Fab Fragment (HPAB-AP295-YC-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP292-YC-S(P) | Human Anti-CLEC14A Recombinant Antibody; scFv Fragment (HPAB-AP292-YC-S(P)) | ELISA, Block | Human scFv |
| HPAB-AP293-YC-S(P) | Human Anti-CLEC14A Recombinant Antibody; scFv Fragment (HPAB-AP293-YC-S(P)) | ELISA, Block | Human scFv |
| HPAB-0522YY-S(P) | Mouse Anti-CLEC14A Recombinant Antibody; scFv Fragment (HPAB-0522YY-S(P)) | FC, Block | Mouse scFv |
| HPAB-0523YY-S(P) | Mouse Anti-CLEC14A Recombinant Antibody; scFv Fragment (HPAB-0523YY-S(P)) | FC, Block | Mouse scFv |
| HPAB-0525YY-S(P) | Mouse Anti-CLEC14A Recombinant Antibody; scFv Fragment (HPAB-0525YY-S(P)) | FC, Block | Mouse scFv |
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