Recombinant Anti-Clec7a Vesicular Antibody, EV Displayed (VS-0425-YC217) (CAT#: VS-0425-YC217)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• Clec7a

• Host Animal
• Rat

• Antibody Isotype
• IgG2a kappa

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• Protein A

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• C-type lectin domain containing 7A

• Biological Process
• Immunity, Inflammatory response, Innate immunity

• Molecular Function
• Receptor

• Introduction
• This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

• Alternative Names
• CD369, CLECSF12, DECTIN-1, hDectin-1, SCARE2

• Gene ID
• 64581

• UniProt ID
• Q9BXN2

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