Recombinant Mouse Anti-CR1 Antibody (clone 6H10-8B7-9G10) (CAT#: VS3-FY410)
This product is a recombinant mouse antibody that recognizes human CR1 protein. The mAb was purified by affinity chromatography.
Specific Inquiry
IHC
Figure 1. Recombinant Mouse Anti-CR1 Antibody (clone 6H10-8B7-9G10) in IHC.
Immunohistochemical analysis of paraffin-embedded follicular lymphoma using CD35 antibody. High pressure and high temperature sodium citrate pH 6.0 for antigen retrieval.
Specifications
- Immunogen
- Synthesized peptide derived from human CD35
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human CR1
- Species Reactivity
- Human
- Clone
- 6H10-8B7-9G10
- Applications
- Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Chromatography Purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS pH 7.3, 50% Glycerol, 0.5% BSA
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry: 1/100-1/500
Target
- Alternative Names
- Complement C3b/C4b Receptor 1 (Knops Blood Group); Complement Component (3b/4b) Receptor 1 (Knops Blood Group); C3b/C4b Receptor; CD35 Antigen; C3BR; Complement Component (3b/4b) Receptor 1, Including Knops Blood Group System; Complement Component 3b/4b Receptor 1 (Knops Blood Group)
- Gene ID
- 1378
- UniProt ID
- P17927
- Sequence Similarities
- Belongs to the receptors of complement activation (RCA) family.
- Cellular Localization
- Membrane
- Protein Refseq
- NP_000564.2; NP_000642.3
- Function
- Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069).
Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069).
Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757).
Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728).
(Microbial infection) Acts as a receptor for Epstein-Barr virus.
Recommended Products
Secondary Antibody
Isotype Control
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Non-Human Primate (NHP) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-240 | Recombinant Human Anti-human CR1 Antibody | ELISA, IP, FuncS | IgG |
| HPAB-J0316-YC | Human Anti-CR1 Recombinant Antibody (HPAB-J0316-YC) | ELISA | Human HC IgG2 |
| HPAB-J0317-YC | Human Anti-CR1 Recombinant Antibody (HPAB-J0317-YC) | ELISA | Human HC IgG3 |
| ZG-0621J | Rabbit Anti-CR1 Recombinant Antibody (clone 9A9) | ELISA, IHC | Rabbit IgG |
| VS3-WK1376 | Mouse Anti-CR1 Recombinant Antibody (clone PT0039) | IHC-P | Mouse IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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