Recombinant Mouse Anti-CR1 Antibody (clone 6H10-8B7-9G10) (CAT#: VS3-FY410)
This product is a recombinant mouse antibody that recognizes human CR1 protein. The mAb was purified by affinity chromatography.
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IHC
Figure 1. Recombinant Mouse Anti-CR1 Antibody (clone 6H10-8B7-9G10) in IHC.
Immunohistochemical analysis of paraffin-embedded follicular lymphoma using CD35 antibody. High pressure and high temperature sodium citrate pH 6.0 for antigen retrieval.
Specifications
- Immunogen
- Synthesized peptide derived from human CD35
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human CR1
- Species Reactivity
- Human
- Clone
- 6H10-8B7-9G10
- Applications
- Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Chromatography Purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS pH 7.3, 50% Glycerol, 0.5% BSA
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry: 1/100-1/500
Target
- Alternative Names
- Complement C3b/C4b Receptor 1 (Knops Blood Group); Complement Component (3b/4b) Receptor 1 (Knops Blood Group); C3b/C4b Receptor; CD35 Antigen; C3BR; Complement Component (3b/4b) Receptor 1, Including Knops Blood Group System; Complement Component 3b/4b Receptor 1 (Knops Blood Group)
- Gene ID
- 1378
- UniProt ID
- P17927
- Sequence Similarities
- Belongs to the receptors of complement activation (RCA) family.
- Cellular Localization
- Membrane
- Protein Refseq
- NP_000564.2; NP_000642.3
- Function
- Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069).
Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069).
Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757).
Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728).
(Microbial infection) Acts as a receptor for Epstein-Barr virus.
Recommended Products
Secondary Antibody
Isotype Control
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-240-F(E) | Recombinant Anti-human CR1 Antibody Fab Fragment | WB, FACS, FuncS | Fab |
| HPAB-0421-CN-F(E) | Mouse Anti-CR1 Recombinant Antibody (clone E11); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0422-CN-F(E) | Mouse Anti-CR1 Recombinant Antibody (clone EDIVH1/VL1); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0423-CN-F(E) | Mouse Anti-CR1 Recombinant Antibody (clone EDI19E9); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0424-CN-F(E) | Human Anti-CR1 Recombinant Antibody (clone EDI3G4); Fab Fragment | ELISA, FC | Human Fab |
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For Research Use Only. Not For Clinical Use.
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