Recombinant Anti-CXCR5 Vesicular Antibody, EV Displayed (VS-0425-YC230)

Name: Recombinant Anti-CXCR5 Vesicular Antibody, EV Displayed (VS-0425-YC230)
SKU: VS-0425-YC230
Rating: 5 (1 reviews)

CAT#: VS-0425-YC230

The Recombinant Anti-CXCR5 Vesicular Antibody, EV Displayed (VS-0425-YC230) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CXCR5-expressed cells or tissues. The CXCR5 is a chemokine receptor associated with diseases like Burkitt Lymphoma. It is involved in pathways like G-protein coupled receptor activity.

Gene Expression

Normal Tissue Figure 1 Skin

Fibroblasts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_B_8_1.jpg

Normal Tissue Figure 2 Lymph node

Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_A_7_8.jpg

Normal Tissue Figure 3 Colon

Endocrine cells Staining: Medium Intensity: Moderate Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes - Fibroblasts Staining: Low Intensity: Weak Goblet cells Staining: Medium Intensity: Moderate Quantity:>75% Mucosal lymphoid cells Staining: High Intensity: Strong Quantity: 75%-25%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_A_7_3.jpg

Normal Tissue Figure 4 Liver

Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_A_7_4.jpg

Normal Tissue Figure 5 Kidney

Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_A_8_5.jpg

Normal Tissue Figure 6 Testis

Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_A_5_6.jpg

RNA Expression Figure 7 RNA cell line category: Group enriched (Daudi, U-698)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160683-CXCR5

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Recombinant Antibody

Application
ELISA, FC, Cell-uptake

Product Type
Ab-Fc-EVs

Antibody Quantification (Ab/EV)
~100 Ab/EV

Target
CXCR5

Host Animal
Human

Antibody Isotype
IgG

Expression Cell
Mammalian cell

Engineered EVs

EV-sorting domain
CD63

Fc-binding domain
z domain

EV Size
30~150 nm

Producing Cell
HEK293F

Isolation Method
Gradient centrifugation

Purification
qEV size exclusion chromatography

Binding Affinity
Kd = 0.85 µg/mL

Concentration
1 x 10¹⁰

Size
1 mL

Buffer
PBS

Storage
Store at -80°C for 12 months

Target

Full Name
C-X-C motif chemokine receptor 5

Biological Process
B-cell activation

Molecular Function
G-protein coupled receptor, Receptor, Transducer

Introduction
CXCR5 (C-X-C Motif Chemokine Receptor 5) is a Protein Coding gene. Diseases associated with CXCR5 include Burkitt Lymphoma and Lymphoma. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CXCR3.

Alternative Names
BLR1, CD185, MDR15

Gene ID
643

UniProt ID
P32302

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Datasheet

Datasheet - VS-0425-YC230.pdf

MSDS

MSDS - VS-0425-YC230.pdf

COA

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