Recombinant Anti-EDAR Vesicular Antibody, EV Displayed (VS-0425-YC490)
CAT#: VS-0425-YC490
The Recombinant Anti-EDAR Vesicular Antibody, EV Displayed (VS-0425-YC490) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to EDAR-expressed cells or tissues. EDAR is a member of the TNF receptor family that engages with ectodysplasin A, activating key signaling pathways essential for ectodermal development. Mutations in EDAR are linked to hypohidrotic ectodermal dysplasia.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human rectum
Immunohistochemical staining of human rectum shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42292/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42292/93789_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42292/93789_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42292/93789_A_8_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42292/93789_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42292/93789_A_4_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42292/93789_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (CAPAN-2, HaCaT, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135960-EDAR
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Recombinant Antibody
- Application
- Agonist, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- EDAR
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Ectodysplasin A receptor
- Biological Process
- Apoptosis, Differentiation
- Molecular Function
- Developmental protein, Receptor
- Introduction
- This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.
- Alternative Names
- DL, ED1R, ED3, ED5, EDA1R, EDA3
- Gene ID
- 10913
- UniProt ID
- Q9UNE0
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "EDAR"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1090 | Hi-Affi™ Rabbit Anti-EDAR Recombinant Antibody (clone DS1090AB) | WB, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0045-LS-F(E) | Human Anti-EDAR Recombinant Antibody; Fab Fragment (HPAB-0045-LS-F(E)) | ELISA, WB, FC | Human Fab |
| HPAB-0046-LS-F(E) | Human Anti-EDAR Recombinant Antibody; Fab Fragment (HPAB-0046-LS-F(E)) | ELISA, WB, FC | Human Fab |
| HPAB-0047-LS-F(E) | Human Anti-EDAR Recombinant Antibody; Fab Fragment (HPAB-0047-LS-F(E)) | ELISA, WB, FC | Human Fab |
| FAMAB-0089JF-S(P) | Mouse Anti-EDAR Recombinant Antibody (clone EDAR8); scFv Fragment | WB, FACS, ELISA, FuncS | Mouse scFv |
| FAMAB-0090JF-S(P) | Mouse Anti-EDAR Recombinant Antibody (clone EDAR9); scFv Fragment | WB, FACS, ELISA, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0045-LS-S(P) | Human Anti-EDAR Recombinant Antibody; scFv Fragment (HPAB-0045-LS-S(P)) | ELISA, WB, FC | Human scFv |
| HPAB-0046-LS-S(P) | Human Anti-EDAR Recombinant Antibody; scFv Fragment (HPAB-0046-LS-S(P)) | ELISA, WB, FC | Human scFv |
| HPAB-0047-LS-S(P) | Human Anti-EDAR Recombinant Antibody; scFv Fragment (HPAB-0047-LS-S(P)) | ELISA, WB, FC | Human scFv |
| FAMAB-0089JF-F(E) | Mouse Anti-EDAR Recombinant Antibody (clone EDAR8); Fab Fragment | WB, FACS, ELISA, FuncS | Mouse Fab |
| FAMAB-0090JF-F(E) | Mouse Anti-EDAR Recombinant Antibody (clone EDAR9); Fab Fragment | WB, FACS, ELISA, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0065-YC | Human Anti-EDAR Recombinant Antibody (HPAB-J0065-YC) | ELISA, WB, FC, Agonist | Human IgG1 |
| HPAB-J0066-YC | Human Anti-EDAR Recombinant Antibody (HPAB-J0066-YC) | ELISA, WB, FC, Agonist, FuncS | Human IgG1 |
| HPAB-J0067-YC | Human Anti-EDAR Recombinant Antibody (HPAB-J0067-YC) | ELISA, Agonist | Human IgG1 |
| FAMAB-0089JF | Mouse Anti-EDAR Recombinant Antibody (clone EDAR8) | WB, ELISA, IHC | Mouse IgG1 |
| FAMAB-0090JF | Mouse Anti-EDAR Recombinant Antibody (clone EDAR9) | WB, FACS, ELISA, FuncS | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY23 | Mouse Anti-EDAR Agonistic Antibody (clone EDAR12) | WB, ELISA, Agonistic assays, SPR | Mouse IgG1, kappa |
| VS-0724-XY24 | Rabbit Anti-EDAR Agonistic Antibody (VS-0724-XY24) | WB, ELISA, Agonistic assays, SPR | Rabbit IgG, kappa |
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