Recombinant Anti-EFNB3 Vesicular Antibody, EV Displayed (VS-0425-YC44)
CAT#: VS-0425-YC44
The Recombinant Anti-EFNB3 Vesicular Antibody, EV Displayed (VS-0425-YC44) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to EFNB3-expressed cells or tissues. The EFNB3 protein, belonging to the ephrin family, plays a significant role in brain development, particularly the forebrain.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human hippocampus
Immunohistochemical staining of human hippocampus shows strong cytoplasmic positivity in subset of neuronal cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1623/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1623/16222_B_7_5.jpg
Normal Tissue
Figure 3 Hippocampus
Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1623/16222_B_8_6.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1623/15988_A_8_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1623/15988_A_7_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (AF22, AN3-CA, hTERT-RPE1, SH-SY5Y)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000108947-EFNB3
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- EFNB3
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Ephrin B3
- Biological Process
- Differentiation, Host-virus interaction, Neurogenesis
- Molecular Function
- Developmental protein, Host cell receptor for virus entry, Receptor
- Introduction
- EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
- Alternative Names
- EPLG8, LERK-8
- Gene ID
- 1949
- UniProt ID
- Q15768
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Datasheet
MSDS
COA
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See other products for "EFNB3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2655z | Mouse Anti-EFNB3 Recombinant Antibody (MOB-2655z) | WB | Mouse IgG2b |
| MOB-0677CT | Recombinant Mouse anti-Human EFNB3 Monoclonal antibody (NN0375- 23Y2) | WB | |
| VS-0224-XY39 | Mouse Anti-EFNB3 Recombinant Antibody (VS-0224-XY39) | ELISA, WB, IF, IP | Mouse IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2655z-F(E) | Recombinant Anti-Human EFNB3 Antibody Fab Fragment | ELISA, FacS, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2655z-S(P) | Recombinant Anti-Human EFNB3 Antibody scFv Fragment | IF, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2177 | Anti-EFNB3 Immunohistochemistry Kit | IHC |
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