Recombinant Anti-EMP2 Vesicular Antibody, EV Displayed (VS-0425-YC177) (CAT#: VS-0425-YC177)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• EMP2

• Host Animal
• Human

• Antibody Isotype
• IgG

• Species Reactivity
• Mouse

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• z domain

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Binding Affinity
• Kd = 0.85 µg/mL

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Epithelial membrane protein 2

• Cellular Localization
• Nucleoplasm, Cytosol

• Introduction
• Enables integrin binding activity. Involved in several processes, including early endosome to late endosome transport; embryonic process involved in female pregnancy; and protein localization to cell surface. Acts upstream of or within positive regulation of integrin-mediated signaling pathway. Located in Golgi apparatus; apical plasma membrane; and cell surface. Colocalizes with cytoplasmic vesicle; membrane raft; and plasma membrane. Is expressed in several structures, including alimentary system; endometrium; medulla oblongata lateral wall; respiratory system; and sensory organ. Used to study placental insufficiency. Human ortholog(s) of this gene implicated in nephrotic syndrome type 10. Orthologous to human EMP2 (epithelial membrane protein 2).

• Alternative Names
• XMP

• Gene ID
• 13731

• UniProt ID
• O88662

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