Recombinant Anti-EMP2 Vesicular Antibody, EV Displayed (VS-0425-YC177)
CAT#: VS-0425-YC177
The Recombinant Anti-EMP2 Vesicular Antibody, EV Displayed (VS-0425-YC177) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to EMP2-expressed cells or tissues. The EMP2 protein enables integrin binding activity and is involved in various processes, including endosome transport and protein localization, expressed in structures like the alimentary system and respiratory system.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14711/121_C8_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human lung
Immunohistochemical staining of human lung shows strong cytoplasmic and membranous positivity in pneumocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/70816/169358_A_2_4_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14711/172_C8_1_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14711/34585_B_8_5.jpg
Normal Tissue
Figure 5 Lung
Alveolar cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Macrophages
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14711/34585_A_2_4.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14711/34585_A_8_3.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14711/34585_A_8_5.jpg
Normal Tissue
Figure 8 Lymph node
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14711/34585_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (MCF7, RT4, SK-BR-3, T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000213853-EMP2
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- EMP2
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Epithelial membrane protein 2
- Cellular Localization
- Nucleoplasm, Cytosol
- Introduction
- Enables integrin binding activity. Involved in several processes, including early endosome to late endosome transport; embryonic process involved in female pregnancy; and protein localization to cell surface. Acts upstream of or within positive regulation of integrin-mediated signaling pathway. Located in Golgi apparatus; apical plasma membrane; and cell surface. Colocalizes with cytoplasmic vesicle; membrane raft; and plasma membrane. Is expressed in several structures, including alimentary system; endometrium; medulla oblongata lateral wall; respiratory system; and sensory organ. Used to study placental insufficiency. Human ortholog(s) of this gene implicated in nephrotic syndrome type 10. Orthologous to human EMP2 (epithelial membrane protein 2).
- Alternative Names
- XMP
- Gene ID
- 13731
- UniProt ID
- O88662
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Datasheet
MSDS
COA
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See other products for "EMP2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-317 | Recombinant Anti-human EMP2 Antibody | WB, Neut, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-317-F(E) | Recombinant Anti-human EMP2 Antibody Fab Fragment | IP, IF, FuncS | Fab |
| CAT | Product Name | Application | Type |
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| MOB-317-S(P) | Recombinant Anti-human EMP2 Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-231CL | Human Anti-EMP2 Recombinant Antibody (TAB-231CL) | ELISA | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-332MZ | Human Anti-EMP2 Recombinant Antibody (TAB-332MZ) | FC | Human IgG |
| TAB-332MZ-F(E) | Human Anti-EMP2 Recombinant Antibody; Fab Fragment (TAB-332MZ-F(E)) | FC | Human Fab |
| TAB-333MZ-F(E) | Human Anti-EMP2 Recombinant Antibody; Fab Fragment (TAB-333MZ-F(E)) | FC | Human Fab |
| TAB-334MZ-F(E) | Human Anti-EMP2 Recombinant Antibody; Fab Fragment (TAB-334MZ-F(E)) | FC | Human Fab |
| TAB-335MZ-F(E) | Human Anti-EMP2 Recombinant Antibody; Fab Fragment (TAB-335MZ-F(E)) | FC | Human Fab |
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