Recombinant Anti-FCGR2B Vesicular Antibody, EV Displayed (VS-0425-YC343)

Name: Recombinant Anti-FCGR2B Vesicular Antibody, EV Displayed (VS-0425-YC343)
SKU: VS-0425-YC343
Rating: 5 (1 reviews)

CAT#: VS-0425-YC343

The Recombinant Anti-FCGR2B Vesicular Antibody, EV Displayed (VS-0425-YC343) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to FCGR2B-expressed cells or tissues. The FCGR2B is a receptor as part of the Fc receptor family, involved in phagocytosis and regulating antibody production, linked to lupus risk.

Gene Expression

Normal Tissue Figure 1 Placenta

Endothelial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Hofbauer cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining: Medium
Intensity: Moderate
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining: High
Intensity: Strong

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7796/18532_A_3_7.jpg

Normal Tissue Figure 2 Lymph node

Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7796/18532_A_8_8.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (Daudi, HMC-1, NB-4, RPMI-8226)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000072694-FCGR2B

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Recombinant Antibody

Application
ELISA, FC, Cell-uptake

Product Type
Ab-Fc-EVs

Antibody Quantification (Ab/EV)
~100 Ab/EV

Target
FCGR2B

Host Animal
Human

Antibody Isotype
IgG

Species Reactivity
Human

Expression Cell
Mammalian cell

Engineered EVs

EV-sorting domain
CD63

Fc-binding domain
z domain

EV Size
30~150 nm

Producing Cell
HEK293F

Isolation Method
Gradient centrifugation

Purification
qEV size exclusion chromatography

Binding Affinity
Kd = 0.85 µg/mL

Concentration
1 x 10¹⁰

Size
1 mL

Buffer
PBS

Storage
Store at -80°C for 12 months

Target

Full Name
Fc gamma receptor IIb

Biological Process
Host-virus interaction

Molecular Function
IgG-binding protein, Receptor

Introduction
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Alternative Names
CD32, CD32B, FCG2, FcgammaRIIb, FCGR2, FcGRIIB

Gene ID
2213

UniProt ID
P31994

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Datasheet

Datasheet - VS-0425-YC343.pdf

MSDS

MSDS - VS-0425-YC343.pdf

COA

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TAB-038WM-S(P)	Human Anti-FCGR2B Recombinant Antibody; scFv Fragment (TAB-038WM-S(P))	ELISA, FC, WB	Humanized scFv
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HPAB-0585-CN	Human Anti-FCGR2B Recombinant Antibody (HPAB-0585-CN)	ELISA, WB, FC, Co-IP	Chimeric (rat/human) IgG1, κ
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HPAB-0587-CN-S(P)	Human Anti-FCGR2B Recombinant Antibody; scFv Fragment (HPAB-0587-CN-S(P))	ELISA, WB, FC, Co-IP	Humanized scFv
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HPAB-0588-CN-S(P)	Human Anti-FCGR2B Recombinant Antibody; scFv Fragment (HPAB-0588-CN-S(P))	ELISA, WB, FC, Co-IP	Humanized scFv
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HPAB-0083-LS-F(E)	Rat Anti-FCGR2B Recombinant Antibody; Fab Fragment (HPAB-0083-LS-F(E))	ELISA, FC, WB	Rat Fab
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