Recombinant Anti-FLT3 Vesicular Antibody, EV Displayed (VS-0425-YC614)
CAT#: VS-0425-YC614
The Recombinant Anti-FLT3 Vesicular Antibody, EV Displayed (VS-0425-YC614) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to FLT3-expressed cells or tissues. FLT3 is a receptor tyrosine kinase regulating hematopoiesis; its constitutive activation is linked to acute leukemias.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47539/1674_A6_32_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (REH, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000122025-FLT3
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- FLT3
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Fms related receptor tyrosine kinase 3
- Biological Process
- Host-virus interaction
- Molecular Function
- Kinase, Receptor, Transferase, Tyrosine-protein kinase
- Cellular Localization
- Endoplasmic reticulum
- Introduction
- This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
- Alternative Names
- CD135, FLK2, STK1
- Gene ID
- 2322
- UniProt ID
- P36888
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Datasheet
MSDS
COA
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