Recombinant Anti-FZD10 Vesicular Antibody, EV Displayed (VS-0425-YC12)
CAT#: VS-0425-YC12
The Recombinant Anti-FZD10 Vesicular Antibody, EV Displayed (VS-0425-YC12) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to FZD10-expressed cells or tissues. The FZD10 is part of the frizzled gene family, encoding 7-transmembrane domain proteins that serve as receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are linked to the beta-catenin canonical signaling pathway. Expression of this intronless gene is significantly upregulated in primary colon cancer.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14484/1943_C2_3_selected.jpg
Normal Tissue
Figure 2 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14484/34140_A_8_8.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14484/34140_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14484/34140_A_7_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14484/34140_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14484/34140_A_9_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14484/34140_A_5_6.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (AF22, BEWO, hTCEpi, RPTEC TERT1, RT4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000111432-FZD10
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- FZD10
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Frizzled class receptor 10
- Biological Process
- Wnt signaling pathway
- Molecular Function
- Developmental protein, G-protein coupled receptor, Receptor, Transducer
- Cellular Localization
- Nucleoplasm
- Introduction
- This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.
- Alternative Names
- CD350
- Gene ID
- 11211
- UniProt ID
- Q9ULW2
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "FZD10"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2133z | Mouse Anti-FZD10 Recombinant Antibody (MOB-2133z) | IHC, ELISA, IF, IP, FC | Mouse IgG |
| HPAB-0028LY | Mouse Anti-FZD10 Recombinant Antibody (HPAB-0028LY) | WB | Mouse IgG |
| VS-0723-WK82 | Human Anti-FZD10 Recombinant Antibody (VS-0723-WK82) | FC | Chimeric (rabbit/human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2133z-F(E) | Recombinant Anti-Human FZD10 Antibody Fab Fragment | WB, IF, FuncS | Fab |
| HPAB-0028LY-F(E) | Mouse Anti-FZD10 Recombinant Antibody; Fab Fragment (HPAB-0028LY-F(E)) | WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2133z-S(P) | Recombinant Anti-Human FZD10 Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
| HPAB-0028LY-S(P) | Mouse Anti-FZD10 Recombinant Antibody; scFv Fragment (HPAB-0028LY-S(P)) | WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-295CL | Anti-Human FZD10 Recombinant Antibody (TAB-295CL) | RIA, IHC | Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-030CQ-S(P) | Human Anti-FZD10 Recombinant Antibody; scFv Fragment (TAB-030CQ-S(P)) | ELISA, FC, WB, Block | Humanized scFv |
| TAB-030CQ-F(E) | Human Anti-FZD10 Recombinant Antibody; Fab Fragment (TAB-030CQ-F(E)) | ELISA, FC, WB, Block | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-031CQ-S(P) | Mouse Anti-FZD10 Recombinant Antibody; scFv Fragment (TAB-031CQ-S(P)) | ELISA, FC, WB, Block | Mouse scFv |
| TAB-032CQ-S(P) | Mouse Anti-FZD10 Recombinant Antibody; scFv Fragment (TAB-032CQ-S(P)) | ELISA, FC, WB, Block | Mouse scFv |
| TAB-031CQ-F(E) | Human Anti-FZD10 Recombinant Antibody; Fab Fragment (TAB-031CQ-F(E)) | ELISA, FC, WB, Block | Chimeric (mouse/human) Fab |
| TAB-032CQ-F(E) | Human Anti-FZD10 Recombinant Antibody; Fab Fragment (TAB-032CQ-F(E)) | ELISA, FC, WB, Block | Chimeric (mouse/human) Fab |
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