Recombinant Anti-GIPR Vesicular Antibody, EV Displayed (VS-0425-YC615)
CAT#: VS-0425-YC615
The Recombinant Anti-GIPR Vesicular Antibody, EV Displayed (VS-0425-YC615) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to GIPR-expressed cells or tissues. GIPR is a gastric inhibitory peptide receptor, influencing insulin secretion and implicated in diabetes and obesity.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line OE19
Immunofluorescent staining of human cell line OE19 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68054/2037_C7_6_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows moderate cytoplasmic positivity in cells in seminiferus ducts and Leydig cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22710/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line K-562
Immunofluorescent staining of human cell line K-562 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68054/1993_C5_2_blue_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22710/112110_B_9_5.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22710/112110_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22710/112110_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22710/112110_A_6_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (HDLM-2, HMC-1, SCLC-21H, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010310-GIPR
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- GIPR
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Gastric inhibitory polypeptide receptor
- Molecular Function
- G-protein coupled receptor, Receptor, Transducer
- Cellular Localization
- Vesicles
- Introduction
- Enables gastric inhibitory peptide receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and positive regulation of insulin secretion. Acts upstream of or within endocrine pancreas development. Is active in plasma membrane. Is expressed in cortical plate; foregut-midgut junction; neck; and thyroid gland. Human ortholog(s) of this gene implicated in cardiovascular system disease; diabetes mellitus; obesity; and type 2 diabetes mellitus. Orthologous to human GIPR (gastric inhibitory polypeptide receptor).
- Alternative Names
- GIP-R, Gm1081, Gm160
- Gene ID
- 381853
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| PFBL-103 | Human Anti-GIPR Recombinant Antibody (clone Gipg013); Fab Fragment | ELISA, Block, FuncS | Human Fab |
| HPAB-0181-WJ-F(E) | Mouse Anti-GIPR Recombinant Antibody; Fab Fragment (HPAB-0181-WJ-F(E)) | ELISA, FC | Mouse Fab |
| PABJ-0036-F(E) | Human Anti-Gipr Recombinant Antibody (clone mab1); Fab fragment | ELISA, FuncS | Human Fab |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| NEUT-882CQ | Mouse Anti-GIPR Recombinant Antibody (clone CBL805) | Neut, FC, CyTOF® | Mouse IgG1 |
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