Recombinant Anti-GLP1R Vesicular Antibody, EV Displayed (VS-0425-YC612)
CAT#: VS-0425-YC612
The Recombinant Anti-GLP1R Vesicular Antibody, EV Displayed (VS-0425-YC612) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to GLP1R-expressed cells or tissues. GLP1R is a receptor for glucagon-like peptide 1, key in insulin secretion and type 2 diabetes treatment.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (NTERA-2, SCLC-21H)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000112164-GLP1R
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Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- GLP1R
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Monkey
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Glucagon like peptide 1 receptor
- Molecular Function
- G-protein coupled receptor, Receptor, Transducer
- Introduction
- This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
- Alternative Names
- GLP-1R
- Gene ID
- 2740
- UniProt ID
- P43220
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| HPAB-0385-YC-S(P) | Mouse Anti-GLP1R Recombinant Antibody (clone m38C2); scFv Fragment | FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
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| HPAB-0385-YC-F(E) | Mouse Anti-GLP1R Recombinant Antibody (clone m38C2); Fab Fragment | FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
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