Recombinant Anti-GP6 Vesicular Antibody, EV Displayed (VS-0425-YC373)
CAT#: VS-0425-YC373
The Recombinant Anti-GP6 Vesicular Antibody, EV Displayed (VS-0425-YC373) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to GP6-expressed cells or tissues. The GP6 is a platelet receptor crucial for collagen-induced aggregation, linked to bleeding disorders like BDPLT11.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47611/1925_A11_24_cr5cd55a323d93f_selected.jpg
Normal Tissue
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in megakaryocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (HEL, K-562, U-2 OS)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000088053-GP6
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- GP6
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Glycoprotein VI platelet
- Biological Process
- Blood coagulation, Hemostasis
- Molecular Function
- Receptor
- Cellular Localization
- Plasma membrane
- Introduction
- This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11).
- Alternative Names
- GPVI
- Gene ID
- 51206
- UniProt ID
- Q9HCN6
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "GP6"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-003CT | Anti-Human GPVI Recombinant Antibody (1C3) | Funcs, ELISA, Inhib, FC | Human antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-005CT | Mouse Anti-GP6 Recombinant Antibody (TAB-005CT) | WB, ELISA, Block | Mouse IgG1, κ |
| TAB-005CT-S(P) | Mouse Anti-GP6 Recombinant Antibody; scFv Fragment (TAB-005CT-S(P)) | WB, ELISA, Block | Mouse scFv |
| TAB-005CT-F(E) | Mouse Anti-GP6 Recombinant Antibody; Fab Fragment (TAB-005CT-F(E)) | WB, ELISA, Block | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1483 | Hi-Affi™ Rabbit Anti-GP6 Recombinant Antibody (clone DS1483AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0002-CN | Human Anti-GP6 Recombinant Antibody (HPAB-0002-CN) | FC, WB | Humanized IgG |
| HPAB-0003-CN | Human Anti-GP6 Recombinant Antibody (HPAB-0003-CN) | FC, WB | Humanized IgG |
| FAMAB-0288JF | Human Anti-GP6 Recombinant Antibody (clone 10B12) | FC, ELISA, FuncS | Human IgG |
| FAMAB-0289JF | Human Anti-GP6 Recombinant Antibody (FAMAB-0289JF) | FC, ELISA, FuncS | Human IgG |
| VS-0723-WK132 | Human Anti-GP6 Recombinant Antibody (VS-0723-WK132) | FC | Chimeric (rabbit/human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0002-CN-F(E) | Human Anti-GP6 Recombinant Antibody; Fab Fragment (HPAB-0002-CN-F(E)) | FC, WB | Humanized Fab |
| HPAB-0133CQ-F(E) | Human Anti-GP6 Recombinant Antibody (clone hGP 5C4); Fab Fragment | ELISA, FC, Inhib, FuncS | Humanized Fab |
| FAMAB-0101JF-F(E) | Mouse Anti-GP6 Recombinant Antibody (clone 12A5); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
| FAMAB-0288JF-F(E) | Human Anti-GP6 Recombinant Antibody (clone 10B12); Fab Fragment | FC, ELISA, FuncS | Human Fab |
| FAMAB-0289JF-F(E) | Human Anti-GP6 Recombinant Antibody Fab Fragment (FAMAB-0289JF-F(E)) | FC, ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1711-FY-F(E) | Mouse Anti-GP6 Recombinant Antibody (clone F1245-4-1); scFv Fragment | ELISA, WB, IHC | Mouse scFv |
| HPAB-1712-FY-F(E) | Mouse Anti-GP6 Recombinant Antibody (clone F1245-5-1); scFv Fragment | ELISA, WB, IHC | Mouse scFv |
| HPAB-1713-FY-F(E) | Mouse Anti-GP6 Recombinant Antibody (clone F1245-6-2); scFv Fragment | ELISA, WB, IHC | Mouse scFv |
| HPAB-1714-FY-F(E) | Human Anti-GP6 Recombinant Antibody (clone F1232-7-1); scFv Fragment | ELISA | Human scFv |
| HPAB-1715-FY-F(E) | Human Anti-GP6 Recombinant Antibody (clone F1232-18-3); scFv Fragment | ELISA | Human scFv |
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