Recombinant Anti-GPA33 Vesicular Antibody, EV Displayed (VS-0425-YC555)
CAT#: VS-0425-YC555
The Recombinant Anti-GPA33 Vesicular Antibody, EV Displayed (VS-0425-YC555) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to GPA33-expressed cells or tissues. GPA33 is a glycoprotein highly expressed in colon cancers, featuring both surface antigen and signal transduction roles. It is part of the immunoglobulin superfamily.
Gene Expression
Normal Tissue
Figure 1 High expression in colon
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/ihc_selected.jpg
Normal Tissue
Figure 2 Low expression in liver
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/43100_A_7_4_val_selected.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/43100_A_9_3.jpg
Normal Tissue
Figure 4 Appendix
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes - Gradient Gradient: Ascending Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/43100_A_2_2.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143167-GPA33
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- GPA33
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Glycoprotein A33
- Introduction
- The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily.
- Alternative Names
- A33
- Gene ID
- 10223
- UniProt ID
- Q99795
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| MOR-1485 | Hi-Affi™ Rabbit Anti-GPA33 Recombinant Antibody (clone DS1485AB) | IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| MOB-069LC | Rat Anti-GPA33 Recombinant Antibody (clone YC069) | ELISA, FC, WB | Rat IgG |
| HPAB-0521-YJ | Human Anti-GPA33 Recombinant Antibody (HPAB-0521-YJ) | WB, IP, FC, ELISA, FuncS | Chimeric (Mouse/Human) IgG |
| HPAB-0522-YJ | Human Anti-GPA33 Recombinant Antibody (HPAB-0522-YJ) | WB, IP, FC, ELISA, FuncS | Humanized IgG |
| ZG-0114U | Rabbit Anti-GPA33 Recombinant Antibody (clone 4H4) | ELISA, IHC | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1717-FY-S(P) | Human Anti-GPA33 Recombinant Antibody (clone 263A17); Fab Fragment | ELISA | Human Fab |
| HPAB-1718-FY-S(P) | Human Anti-GPA33 Recombinant Antibody (clone 125M10AA); Fab Fragment | ELISA | Human Fab |
| HPAB-1719-FY-S(P) | Human Anti-GPA33 Recombinant Antibody (clone 125M165DAAA); Fab Fragment | ELISA | Human Fab |
| HPAB-0521-YJ-F(E) | Human Anti-GPA33 Recombinant Antibody; Fab Fragment (HPAB-0521-YJ-F(E)) | WB, IP, FC, ELISA, FuncS | Chimeric (Mouse/Human) Fab |
| HPAB-0522-YJ-F(E) | Human Anti-GPA33 Recombinant Antibody; Fab Fragment (HPAB-0522-YJ-F(E)) | WB, IP, FC, ELISA, FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY112 | AbPlus™ Anti-GPA33 Magnetic Beads (VS-0424-XY112) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY194 | Human Anti-GPA33 scFv-Fc Chimera (VS-0325-FY194) | FC, Cyt, IHC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2878 | Anti-GPA33 Immunohistochemistry Kit | IHC |
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