Recombinant Anti-HPN Vesicular Antibody, EV Displayed (VS-0425-YC349)
CAT#: VS-0425-YC349
The Recombinant Anti-HPN Vesicular Antibody, EV Displayed (VS-0425-YC349) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to HPN-expressed cells or tissues. The HPN is a transmembrane protease linked to cancer progression, influencing diverse cellular functions, including coagulation.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6804/19524_B_7_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6804/19524_A_7_3.jpg
Normal Tissue
Figure 3 Liver
Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6804/19524_A_8_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6804/19524_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6804/19524_A_4_6.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (EFO-21, Hep G2, T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105707-HPN
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- HPN
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Hepsin
- Molecular Function
- Hydrolase, Protease, Serine protease
- Introduction
- This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
- Alternative Names
- TMPRSS1
- Gene ID
- 3249
- UniProt ID
- P05981
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "HPN"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1314-VHH | Recombinant Anti-Human HPN VHH Single Domain Antibody | ICC, FC, WB, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2151z | Mouse Anti-HPN Recombinant Antibody (clone 19A1) | WB, ELISA, IP | Mouse IgG2a, κ |
| PABL-125 | Human Anti-HPN Recombinant Antibody (PABL-125) | WB, ELISA, FuncS | Human IgG |
| HPAB-0223-LSX | Mouse Anti-HPN Recombinant Antibody (clone 25) | ELISA | Mouse IgG |
| HPAB-0224-LSX | Human Anti-HPN Recombinant Antibody (clone mAb55) | ELISA, FC, Inhib | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-125 | Human Anti-HPN Recombinant Antibody scFv Fragment (PSBL-125) | WB, ELISA, FuncS | Human scFv |
| HPAB-0223-LSX-S(P) | Mouse Anti-HPN Recombinant Antibody (clone 25); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0224-LSX-S(P) | Human Anti-HPN Recombinant Antibody (clone mAb55); scFv Fragment | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-125 | Human Anti-HPN Recombinant Antibody Fab Fragment (PFBL-125) | WB, ELISA, FuncS | Human Fab |
| HPAB-0223-LSX-F(E) | Mouse Anti-HPN Recombinant Antibody (clone 25); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0224-LSX-F(E) | Human Anti-HPN Recombinant Antibody (clone mAb55); Fab Fragment | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-029CT | Anti-Human Hepsin Recombinant Antibody (hH35) | ELISA, WB | Humanized antibody |
| TAB-031CT | Human Anti-HPN Recombinant Antibody (TAB-031CT) | WB | Humanized IgG |
| TAB-029CT-S(P) | Anti-Human Hepsin Recombinant Antibody scFv Fragment (hH35) | ELISA, WB | Humanized antibody |
| TAB-031CT-S(P) | Human Anti-HPN Recombinant Antibody; scFv Fragment (TAB-031CT-S(P)) | WB | Humanized scFv |
| TAB-029CT-F(E) | Anti-Human Hepsin Recombinant Antibody Fab Fragment (hH35) | ELISA, WB | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-030CT | Anti-Human Hepsin Recombinant Antibody (Mab2.7.35) | ELISA, Inhibition, FC | Chimeric antibody (mouse/human) |
| TAB-030CT-S(P) | Anti-Human Hepsin Recombinant Antibody scFv Fragment (Mab2.7.35) | ELISA, Inhibition, FC | Chimeric antibody (mouse/human) |
| TAB-030CT-F(E) | Anti-Human Hepsin Recombinant Antibody Fab Fragment (Mab2.7.35) | ELISA, Inhibition, FC | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3274 | Anti-HPN Immunohistochemistry Kit | IHC |
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