Recombinant Anti-IL17RA Vesicular Antibody, EV Displayed (VS-0425-YC580)
CAT#: VS-0425-YC580
The Recombinant Anti-IL17RA Vesicular Antibody, EV Displayed (VS-0425-YC580) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to IL17RA-expressed cells or tissues. IL17RA is a type I membrane glycoprotein receptor for interleukin 17A, involved in inflammatory and autoimmune diseases like rheumatoid arthritis. It binds interleukin 17A with low affinity and likely has a multimeric structure.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24996/if_selected.jpg
Normal Tissue
Figure 2 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24996/59803_A_7_3.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24996/59803_A_7_4.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (HL-60, NB-4, THP-1)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000177663-IL17RA
❮
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- IL17RA
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Interleukin 17 receptor A
- Biological Process
- Adaptive immunity, Host-virus interaction, Immunity, Inflammatory response, Innate immunity
- Molecular Function
- Receptor
- Cellular Localization
- Nucleoplasm, Cytosol
- Introduction
- Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]
- Alternative Names
- CD217, CDw217, hIL-17R, IL-17RA, IL17R
- Gene ID
- 23765
- UniProt ID
- Q96F46
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-134 | Afuco™ Anti-IL17RA Recombinant Antibody (AFC-TAB-134), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | Human IgG1, κ |
| AFC-TAB-217 | Afuco™ Anti-IL17RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-217) | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0318-WJ | Human Anti-IL17RA Recombinant Antibody (HPAB-0318-WJ) | ELISA, Neut | Humanized IgG |
| HPAB-0319-WJ | Human Anti-IL17RA Recombinant Antibody (HPAB-0319-WJ) | ELISA, Neut | Humanized IgG |
| HPAB-0320-WJ | Human Anti-IL17RA Recombinant Antibody (HPAB-0320-WJ) | ELISA, Neut | Humanized IgG |
| HPAB-0853-FY | Human Anti-IL17RA Recombinant Antibody (HPAB-0853-FY) | Activ | Human IgG |
| HPAB-0854-FY | Human Anti-IL17RA Recombinant Antibody (HPAB-0854-FY) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0318-WJ-S(P) | Human Anti-IL17RA Recombinant Antibody; scFv Fragment (HPAB-0318-WJ-S(P)) | ELISA, Neut | Humanized scFv |
| HPAB-0319-WJ-S(P) | Human Anti-IL17RA Recombinant Antibody; scFv Fragment (HPAB-0319-WJ-S(P)) | ELISA, Neut | Humanized scFv |
| HPAB-0320-WJ-S(P) | Human Anti-IL17RA Recombinant Antibody; scFv Fragment (HPAB-0320-WJ-S(P)) | ELISA, Neut | Humanized scFv |
| HPAB-0321-WJ-S(P) | Human Anti-IL17RA Recombinant Antibody; scFv Fragment (HPAB-0321-WJ-S(P)) | ELISA, Neut | Humanized scFv |
| HPAB-0322-WJ-S(P) | Human Anti-IL17RA Recombinant Antibody; scFv Fragment (HPAB-0322-WJ-S(P)) | ELISA, Neut | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0318-WJ-F(E) | Human Anti-IL17RA Recombinant Antibody; Fab Fragment (HPAB-0318-WJ-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0853-FY-S(P) | Human Anti-IL17RA Recombinant Antibody; scFv Fragment (HPAB-0853-FY-S(P)) | Activ | Human scFv |
| HPAB-0854-FY-S(P) | Human Anti-IL17RA Recombinant Antibody; scFv Fragment (HPAB-0854-FY-S(P)) | ELISA | Human scFv |
| HPAB-0144-WJ-F(E) | Human Anti-IL17RA Recombinant Antibody; Fab Fragment (HPAB-0144-WJ-F(E)) | ELISA | Humanized Fab |
| HPAB-1557-FY-S(P) | Human Anti-IL17RA Recombinant Antibody; scFv Fragment (HPAB-1557-FY-S(P)) | FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY41 | Human Anti-IL17RA scFv-Fc Chimera (VS-0425-FY41) | WB, ELISA, DB | Human IgG2, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3496 | Anti-IL17RA Immunohistochemistry Kit | IHC |
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