Recombinant Anti-IL4R Vesicular Antibody, EV Displayed (VS-0425-YC103)
CAT#: VS-0425-YC103
The Recombinant Anti-IL4R Vesicular Antibody, EV Displayed (VS-0425-YC103) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to IL4R-expressed cells or tissues. The IL4R is the interleukin-4 receptor alpha chain, involved in immune regulation and IgE production, with polymorphisms linked to various conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to nucleoplasm, plasma membrane & centriolar satellites.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/70380/1812_F10_5_cr59ef13a97c5ff_selected.jpg
Normal Tissue
Figure 2 Tonsil
High expression in tonsil
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/50124/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows distinct cytoplasmic positivity in subsets of cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4451/ihc_selected.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/50124/123264_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/50124/123264_A_8_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HBEC3-KT, HDLM-2, U-698)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077238-IL4R
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- IL4R
- Host Animal
- Human
- Antibody Isotype
- IgG lambda
- Species Reactivity
- Cynomolgus
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Interleukin 4 receptor
- Biological Process
- Immunity
- Molecular Function
- Receptor
- Cellular Localization
- Plasma membrane, Nucleoplasm, Centriolar satellite
- Introduction
- This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
- Alternative Names
- IL-4R
- Gene ID
- 102133649
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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|---|---|---|---|
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| HPAB-0872-FY | Mouse Anti-IL4R Recombinant Antibody (HPAB-0872-FY) | Inhib | Mouse IgG |
| HPAB-0873-FY | Mouse Anti-IL4R Recombinant Antibody (HPAB-0873-FY) | Inhib | Mouse IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L079E | IL4-PE immunotoxin | Cytotoxicity assay, Functional assay | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0004CL | Anti-Human IL4R Recombinant Antibody (12B5) | Inhib, RIA, ELISA, Block | Human antibody |
| TAB-0005CL | Anti-Human IL4R Recombinant Antibody (27A1) | Block, Inhib, ELISA | |
| TAB-0006CL | Anti-Human IL4R Recombinant Antibody (5A1) | Block, Inhib, ELISA | |
| TAB-0007CL | Anti-Human IL4R Recombinant Antibody (63) | Block, Inhib, ELISA | |
| TAB-668LC-F(E) | Anti-human IL4R Fab Fragment | ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1432CQ | Mouse Anti-IL4R Recombinant Antibody (clone CBL439) | WB, FC, IHC, CyTOF, Neut | Mouse IgG2a |
| NEUT-1433CQ | Mouse Anti-IL4R Recombinant Antibody (clone MM0405-4Y44) | WB, Neut, IHC, IHC-P | Mouse IgG1 |
| NEUT-1434CQ | Rabbit Anti-IL4R Recombinant Antibody (clone CBL1006) | Neut | Rabbit IgG |
| NEUT-1435CQ | Rabbit Anti-IL4R Recombinant Antibody (clone CBL998) | Neut | Rabbit IgG |
| NEUT-1436CQ | Mouse Anti-IL4R Recombinant Antibody (clone CBL075) | ELISA, Neut | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4007 | Rabbit Anti-Il4r Recombinant Antibody (clone SI69DS) | ELISA | Rabbit IgG |
| MOR-4274 | Rabbit Anti-IL4R Recombinant Antibody (clone SI357DS) | FC | Rabbit IgG |
| MOR-4275 | Rabbit Anti-IL4R Recombinant Antibody (clone SI358DS) | Neut | Rabbit IgG |
| MOR-4276 | Rabbit Anti-IL4R Recombinant Antibody (clone SI359DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0291-YC-F(E) | Human Anti-IL4R Recombinant Antibody (clone Antibody 1); Fab Fragment | HTRF, FuncS | Human Fab |
| HPAB-1447LY-F(E) | Mouse Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-1447LY-F(E)) | FC, ELISA, Block | Mouse Fab |
| HPAB-1755-FY-S(P) | Human Anti-IL4R Recombinant Antibody; scFv Fragment (HPAB-1755-FY-S(P)) | ELISA | Human scFv |
| HPAB-1756-FY-S(P) | Human Anti-IL4R Recombinant Antibody; scFv Fragment (HPAB-1756-FY-S(P)) | ELISA | Human scFv |
| HPAB-1757-FY-S(P) | Human Anti-IL4R Recombinant Antibody; scFv Fragment (HPAB-1757-FY-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1447LY-S(P) | Mouse Anti-IL4R Recombinant Antibody; scFv Fragment (HPAB-1447LY-S(P)) | FC, ELISA, Block | Mouse scfv |
| HPAB-1448LY-S(P) | Mouse Anti-IL4R Recombinant Antibody; scFv Fragment (HPAB-1448LY-S(P)) | FC, ELISA, Block | Mouse scfv |
| HPAB-1449LY-S(P) | Mouse Anti-IL4R Recombinant Antibody; scFv Fragment (HPAB-1449LY-S(P)) | FC, ELISA, Block | Mouse scfv |
| HPAB-1450LY-S(P) | Mouse Anti-IL4R Recombinant Antibody; scFv Fragment (HPAB-1450LY-S(P)) | FC, ELISA, Block | Mouse scfv |
| HPAB-1451LY-S(P) | Mouse Anti-IL4R Recombinant Antibody; scFv Fragment (HPAB-1451LY-S(P)) | FC, ELISA, Block | Mouse scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY132 | Human Anti-IL4R (clone 12B5) scFv-Fc Chimera | Block | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3535 | Anti-IL4R Immunohistochemistry Kit | IHC |
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