Recombinant Anti-ITGA2 Vesicular Antibody, EV Displayed (VS-0425-YC196)
CAT#: VS-0425-YC196
The Recombinant Anti-ITGA2 Vesicular Antibody, EV Displayed (VS-0425-YC196) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ITGA2-expressed cells or tissues. The ITGA2 is the alpha subunit of a receptor for collagens. It mediates platelet adhesion to the extracellular matrix and is associated with bleeding disorders.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/60991/1358_H10_6_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/60991/1591_A6_2_red_green.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63556/141951_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63556/141951_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63556/141951_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Collecting ducts
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63556/141951_A_9_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63556/141951_A_6_6.jpg
Normal Tissue
Figure 8 Endometrium
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63556/141951_B_6_3.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (BJ hTERT+, HaCaT, hTERT-RPE1, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164171-ITGA2
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ITGA2
- Host Animal
- Human
- Antibody Isotype
- IgG4 kappa
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 1.84 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Integrin subunit alpha 2
- Biological Process
- Cell adhesion, Host-virus interaction
- Molecular Function
- Host cell receptor for virus entry, Integrin, Receptor
- Introduction
- This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
- Alternative Names
- CD49B
- Gene ID
- 3673
- UniProt ID
- P17301
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| TAB-715LC-S(P) | Mouse Anti-ITGA2 Recombinant Antibody; scFv Fragment (TAB-715LC-S(P)) | ELISA | Mouse scFv |
| TAB-714LC-F(E) | Mouse Anti-ITGA2 Recombinant Antibody; Fab Fragment (TAB-714LC-F(E)) | ELISA | Mouse Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| NEUT-1542CQ | Recombinant Mouse Anti-ITGA2 Antibody (HAS-4) | FC, IHC-Fr, ICC, IP, BL | IgG2a, κ |
| CAT | Product Name | Application | Type |
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| NEUT-1543CQ | Recombinant Mouse Anti-ITGA2 Antibody (NEUT-1543CQ) | FC, BL, IP, ELISA | IgG1, κ |
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| CAT | Product Name | Application | Type |
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| MOR-1871 | Hi-Affi™ Recombinant Rabbit Anti-ITGA2 Monoclonal Antibody (DS1871AB) | ICC, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0312-CN | Mouse Anti-ITGA2 Recombinant Antibody (HPAB-0312-CN) | ELISA, IHC, Block | Mouse IgG1, κ |
| HPAB-0313-CN | Human Anti-ITGA2 Recombinant Antibody (HPAB-0313-CN) | ELISA | Chimeric (mouse/human) IgG1, κ |
| MOB-072CQ | Rat Anti-Mouse ITGA2 Antibody | FC | Rat IgG2b |
| FN-219CQ | Recombinant Armenian hamster Anti-ITGA2 Antibody (HMa2) | FC, FuncS | Armenian hamster IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0312-CN-S(P) | Mouse Anti-ITGA2 Recombinant Antibody; scFv Fragment (HPAB-0312-CN-S(P)) | ELISA, IHC, Block | Mouse scFv |
| HPAB-0313-CN-S(P) | Human Anti-ITGA2 Recombinant Antibody; scFv Fragment (HPAB-0313-CN-S(P)) | ELISA | Human scFv |
| HPAB-0314-CN-S(P) | Human Anti-ITGA2 Recombinant Antibody; scFv Fragment (HPAB-0314-CN-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0312-CN-F(E) | Mouse Anti-ITGA2 Recombinant Antibody; Fab Fragment (HPAB-0312-CN-F(E)) | ELISA, IHC, Block | Mouse Fab |
| HPAB-0313-CN-F(E) | Human Anti-ITGA2 Recombinant Antibody; Fab Fragment (HPAB-0313-CN-F(E)) | ELISA | Human Fab |
| HPAB-0314-CN-F(E) | Human Anti-ITGA2 Recombinant Antibody; Fab Fragment (HPAB-0314-CN-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY149 | CytoStream™ Mouse Anti-ITGA2 Recombinant Antibody (VS-0225-XY149) | FC | Mouse IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY137 | Human Anti-ITGA2 (clone Vatelizumab) scFv-Fc Chimera | ELISA, FC | Human IgG4, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3615 | Anti-ITGA2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3616 | Anti-Mouse ITGA2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3617 | Anti-Human ITGA2 Immunohistochemistry Kit | IHC |
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