Recombinant Anti-ITGAE Vesicular Antibody, EV Displayed (VS-0425-YC82)
CAT#: VS-0425-YC82
The Recombinant Anti-ITGAE Vesicular Antibody, EV Displayed (VS-0425-YC82) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ITGAE-expressed cells or tissues. The ITGAE is an alpha integrin involved in adhesion, particularly expressed in intestinal intraepithelial lymphocytes.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows distinct cytoplasmic positivity in intra-epithelial lymphocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36313/ihc_selected.jpg
Normal Tissue
Figure 2 High expression in small intestine
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_4_2_selected.jpg
Normal Tissue
Figure 3 Low expression in cerebral cortex
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_B_9_5_val_selected.jpg
Normal Tissue
Figure 4 Colon
Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_8_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000083457-ITGAE
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ITGAE
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Integrin subunit alpha E
- Biological Process
- Cell adhesion
- Molecular Function
- Integrin, Receptor
- Introduction
- Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation.
- Alternative Names
- CD103, HUMINAE
- Gene ID
- 3682
- UniProt ID
- P38570
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "ITGAE"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1726z | Mouse Anti-ITGAE Recombinant Antibody (clone 23B3) | WB, FC, IHC, IP | Mouse IgG1, κ |
| MOB-0363MZ | Recombinant Mouse Anti-Human Integrin, Alpha E (antigen CD103, Human Mucosal Lymphocyte antigen 1; Alpha Polypeptide) Antibody (clone Cer-ACT9) | ELISA | Mouse antibody |
| FN-104CQ | Recombinant Rat Anti-ITGAE Antibody (M290) | IF, Neut, FC | Rat IgG2a |
| FAMAB-1581CQ | Mouse Anti-ITGAE Recombinant Antibody (clone OX62) | Depletion, IP, MACS, WB, FC, IF, IHC-Fr | Mouse IgG1 |
| ZG-0750F | Mouse Anti-ITGAE Recombinant Antibody (clone AX.14) | FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G046S | Anti-Itgae immunotoxin M290 (IgG)-Sap | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-741LC | Anti-human ITGAE Recombinant Antibody (5E4) (TAB-741LC) | ELISA, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-742LC | Anti-human ITGAE Recombinant Antibody (3G6) (TAB-742LC) | ELISA, FC | |
| TAB-743LC | Anti-human ITGAE Recombinant Antibody (8D5) (TAB-743LC) | ELISA, FC | |
| TAB-741LC-S(P) | Anti-human ITGAE scFv Fragment (5E4) | ELISA, FC | |
| TAB-742LC-S(P) | Anti-human ITGAE scFv Fragment (3G6) | ELISA, FC | |
| TAB-743LC-S(P) | Anti-human ITGAE scFv Fragment (8D5) | ELISA, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-744LC | Anti-human ITGAE Recombinant Antibody (5E4 (IgG1)) (TAB-744LC) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-745LC | Anti-human ITGAE Recombinant Antibody (3G6 (IgG1)) (TAB-745LC) | FC | Chimeric antibody (mouse/human) |
| TAB-744LC-S(P) | Anti-human ITGAE scFv Fragment (5E4 (IgG1)) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-744LC-F(E) | Anti-human ITGAE Fab Fragment (5E4 (IgG1)) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-745LC-F(E) | Anti-human ITGAE Fab Fragment (3G6 (IgG1)) | ELISA, FC | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0296MZ | Chicken Anti-ITGAE Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1558CQ | Recombinant Rat Anti-Itgae Antibody (MAB0828) | BL, FC, IHC-Fr, IP | IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1877 | Hi-Affi™ Recombinant Rabbit Anti-ITGAE Monoclonal Antibody (DS1877AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY71 | Mouse Anti-NHP ITGAE Recombinant Antibody (clone 2G5.1) | IHC, FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3638 | Anti-ITGAE Immunohistochemistry Kit | IHC | |
| VS-0525-XY3639 | Anti-Human ITGAE Immunohistochemistry Kit | IHC |
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