Recombinant Rabbit Anti-Itgal Antibody (clone R08-3I4) (CAT#: VS3-FY771)
This product is a recombinant rabbit antibody that recognizes Itgal. This antibody has been reported for use in Western Blot, Immunohistochemistry-Paraffin. The clone R08-3I4 is specific for human, mouse Itgal. The antigen is mouse cd11a recombinant protein.
Specific Inquiry
IHC-P
Figure 1. Recombinant Rabbit Anti-Itgal Antibody (clone R08-3I4) in IHC-P.
Immunohistochemical analysis of paraffin-embedded mouse lung using Integrin alpha L Antibody. High pressure and high temperature sodium citrate pH 6.0 for antigen retrieval.
Specifications
- Immunogen
- mouse CD11a recombinant protein.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse Itgal
- Species Reactivity
- Human, Mouse
- Clone
- R08-3I4
- Applications
- Western Blot, Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
- MW
- Calculated MW: 128 kDa; Observed MW: 160 kDa
Product Property
- Purification
- Affinity Purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry-Paraffin: 1/50-1/100
Target
- Alternative Names
- Integrin Subunit Alpha L
- Gene ID
- 3683
- UniProt ID
- P20701
- Sequence Similarities
- Belongs to the integrin alpha chain family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.
- Protein Refseq
- NP_001107852.1; NP_002200.2
- Function
- Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364).
Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055).
Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110).
Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992).
Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity).
Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Single Domain Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1129z | Mouse Anti-ITGAL Recombinant Antibody (clone 44C9) | IP, FC, FuncS | Mouse IgG1 |
| PABW-159 | Human Anti-ITGAL Recombinant Antibody (clone AL-57) | WB | Human IgG |
| FAMAB-1185CQ | Mouse Anti-ITGAL Recombinant Antibody (clone YTH 81.5) | FC | Mouse IgG1 |
| ZG-1058F | Mouse Anti-ITGAL Recombinant Antibody (clone NKI (SPV)-L1) | FC, IP, ICC | Mouse IgG1 |
| VS-0224-XY75 | Mouse Anti-ITGAL Recombinant Antibody (VS-0224-XY75) | WB, FC, IP, ICC, RIA | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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