Recombinant Anti-ITGAM Vesicular Antibody, EV Displayed (VS-0425-YC236)
CAT#: VS-0425-YC236
The Recombinant Anti-ITGAM Vesicular Antibody, EV Displayed (VS-0425-YC236) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ITGAM-expressed cells or tissues. The ITGAM is an integrin alpha M chain, forming a leukocyte-specific integrin important for monocyte adherence and phagocytosis.
Gene Expression
Normal Tissue
Figure 1 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2274/158194_A_8_8.jpg
Normal Tissue
Figure 2 Bone marrow
Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2274/158194_B_4_4.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (HMC-1, NB-4, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169896-ITGAM
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ITGAM
- Host Animal
- Mouse
- Antibody Isotype
- IgG2a kappa
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Integrin subunit alpha M
- Biological Process
- Cell adhesion, Immunity, Innate immunity
- Molecular Function
- Integrin, Receptor
- Introduction
- This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
- Alternative Names
- CD11B, CR3A, MAC-1
- Gene ID
- 3684
- UniProt ID
- P11215
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Datasheet
MSDS
COA
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