Recombinant Anti-ITGB6 Vesicular Antibody, EV Displayed (VS-0425-YC511)
CAT#: VS-0425-YC511
The Recombinant Anti-ITGB6 Vesicular Antibody, EV Displayed (VS-0425-YC511) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ITGB6-expressed cells or tissues. ITGB6 is part of integrin receptors and mediates extracellular matrix signaling with multiple transcript variants. ITGB6 functions in cell adhesion.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23626/1423_D12_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human rectum
Immunohistochemical staining of human rectum shows strong cytoplasmic and membranous positivity in granular pattern in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23626/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows strong membranous positivity in urothelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73536/155964_A_5_5_selected.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73536/155964_A_7_3.jpg
Normal Tissue
Figure 5 Gallbladder
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73536/155964_A_5_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73536/155964_A_7_5.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (CAPAN-2, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115221-ITGB6
❮
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Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ITGB6
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Integrin subunit beta 6
- Biological Process
- Cell adhesion, Host-virus interaction
- Molecular Function
- Host cell receptor for virus entry, Integrin, Receptor
- Cellular Localization
- Nucleoplasm, Cell Junctions, Acrosome, Centrosome, Connecting piece, Mid piece, Principal piece, End piece
- Introduction
- This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
- Gene ID
- 3694
- UniProt ID
- P18564
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "ITGB6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1887 | Hi-Affi™ Recombinant Rabbit Anti-ITGB6 Monoclonal Antibody (DS1887AB) | WB, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1772-FY | Human Anti-ITGB6 Recombinant Antibody (HPAB-1772-FY) | Inhib, IHC | Humanized IgG |
| VS3-FY779 | Recombinant Rabbit Anti-ITGB6 Antibody (clone R04-6E9) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1772-FY-F(E) | Human Anti-ITGB6 Recombinant Antibody; Fab Fragment (HPAB-1772-FY-F(E)) | Block | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1772-FY-S(P) | Human Anti-ITGB6 Recombinant Antibody; scFv Fragment (HPAB-1772-FY-S(P)) | Block | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1160 | Anti-ITGB6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3667 | Anti-Rat ITGB6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3666 | Anti-Human ITGB6 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC229 | SmartAb™ Recombinant Anti-ITGB6 pH-dependent Antibody (VS-0825-YC229) | Inhib, IHC | Human IgG |
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