Recombinant Anti-JAML Vesicular Antibody, EV Displayed (VS-0425-YC404) (CAT#: VS-0425-YC404)
The Recombinant Anti-JAML Vesicular Antibody, EV Displayed (VS-0425-YC404) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to JAML-expressed cells or tissues. The JAML is predicted to enable binding and homodimerization, involved in T cell activation and epithelial proliferation in wound healing.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5854/1954_D11_31_cr5dfb7ddd913c7_selected.jpg
(Immunofluorescent staining of human cell line Hep G2 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5854/1954_D11_31_cr5dfb7ddd913c7_selected.jpg
Figure 2 IHC staining of human rectum
(Immunohistochemical staining of human rectum shows moderate cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47919/ihc_selected.jpg
(Immunohistochemical staining of human rectum shows moderate cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47919/ihc_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47919/110784_B_9_5.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47919/110784_B_9_5.jpg
Figure 4 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47919/110784_A_9_3.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47919/110784_A_9_3.jpg
Figure 5 Kidney
(Cells in glomeruli
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Nuclear
Cells in tubules
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47919/110784_A_7_5.jpg
(Cells in glomeruli
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Nuclear
Cells in tubules
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47919/110784_A_7_5.jpg
Figure 6 Testis
(Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47919/110784_A_6_6.jpg
(Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47919/110784_A_6_6.jpg
Figure 7 Bone marrow
(Hematopoietic cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47919/110784_B_4_4.jpg
(Hematopoietic cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47919/110784_B_4_4.jpg
Figure 8 Lymph node
(Non-germinal center cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47919/110784_A_9_8.jpg
(Non-germinal center cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47919/110784_A_9_8.jpg
Figure 9 RNA cell line category: Cell line enriched (HMC-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160593-JAML
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160593-JAML
Recombinant Antibody
- Application
- ELISA, FC, SPR, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- JAML
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Junction adhesion molecule like
- Biological Process
- Cell adhesion, Immunity
- Cellular Localization
- Plasma membrane, Nucleoplasm
- Introduction
- Predicted to enable integrin binding activity and protein homodimerization activity. Involved in gamma-delta T cell activation and positive regulation of epithelial cell proliferation involved in wound healing. Located in plasma membrane. Orthologous to human JAML (junction adhesion molecule like).
- Alternative Names
- AMICA, Amica1, Crea7, Gm638
- Gene ID
- 270152
- UniProt ID
- E9QNV7
Downloads
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Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-650 | Mouse Anti-JAML Recombinant Antibody (clone HL4E10) | FACS, IP, SPR, FC, IF | Mouse IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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