Recombinant Anti-KDR Vesicular Antibody, EV Displayed (VS-0425-YC463) (CAT#: VS-0425-YC463)

• Application
• ELISA, FC, Inhib, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• KDR

• Host Animal
• Mouse

• Antibody Isotype
• IgG

• Species Reactivity
• Human

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• Protein A

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Kinase insert domain receptor

• Biological Process
• Angiogenesis, Differentiation, Host-virus interaction

• Molecular Function
• Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

• Cellular Localization
• Vesicles, Nuclear membrane, Cytosol, Connecting piece, Mid piece, Principal piece

• Introduction
• Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

• Alternative Names
• CD309, FLK1, VEGFR, VEGFR2

• Gene ID
• 3791

• UniProt ID
• P35968

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