Recombinant Anti-KDR Vesicular Antibody, EV Displayed (VS-0425-YC463)
CAT#: VS-0425-YC463
The Recombinant Anti-KDR Vesicular Antibody, EV Displayed (VS-0425-YC463) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to KDR-expressed cells or tissues. The KDR is a receptor for VEGF, mediating endothelial functions like proliferation and implicated in capillary hemangiomas.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to nuclear membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73577/1825_D8_31_cr5ac340707076b_selected.jpg
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Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- KDR
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Kinase insert domain receptor
- Biological Process
- Angiogenesis, Differentiation, Host-virus interaction
- Molecular Function
- Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
- Cellular Localization
- Vesicles, Nuclear membrane, Cytosol, Connecting piece, Mid piece, Principal piece
- Introduction
- Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
- Alternative Names
- CD309, FLK1, VEGFR, VEGFR2
- Gene ID
- 3791
- UniProt ID
- P35968
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Datasheet
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COA
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| NEUT-1622CQ | Recombinant Mouse Anti-KDR Antibody (6B11) | WB, Neut | IgG1 |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-1279-FY-S(P) | Mouse Anti-KDR Recombinant Antibody; scFv Fragment (HPAB-1279-FY-S(P)) | ELISA, FC, Inhib | Mouse scFv |
| HPAB-1280-FY-S(P) | Mouse Anti-KDR Recombinant Antibody; scFv Fragment (HPAB-1280-FY-S(P)) | ELISA, FC, Inhib | Mouse scFv |
| HPAB-1281-FY-S(P) | Mouse Anti-KDR Recombinant Antibody; scFv Fragment (HPAB-1281-FY-S(P)) | ELISA, FC, Inhib | Mouse scFv |
| HPAB-1282-FY-S(P) | Mouse Anti-KDR Recombinant Antibody; scFv Fragment (HPAB-1282-FY-S(P)) | ELISA, FC, Inhib | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-M0127-YC-S(P) | Human Anti-KDR Recombinant Antibody (clone PCABHL3); scFv Fragment | ELISA, Inhib | Humanized scFv |
| HPAB-M0128-YC-S(P) | Human Anti-KDR Recombinant Antibody (clone PCABHL5); scFv Fragment | ELISA, Inhib | Humanized scFv |
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