Recombinant Rat Anti-KITLG Capture Antibody (clone 17E8) (CAT#: VS3-WK1968)
This antibody is a rat recombinant antibody against human KITLG. It was developed by immunization of rat with recombinant human KITLG protein and then was produced as a recombinant antibody. The isotype of this product is rat IgG2a. The sandwich ELISA was established using matched antibody pair 17E8 and 1D11. The clone 17E8 can be used as a capture antibody in ELISA analysis to identify human KITLG.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70395/1515_E4_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70395/1515_E4_1_selected.jpg
Figure 2 IHC staining of human bone marrow
(Immunohistochemical staining of human bone marrow shows nuclear positivity in hematopoietic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70395/159850_B_5_4_selected.jpg
(Immunohistochemical staining of human bone marrow shows nuclear positivity in hematopoietic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70395/159850_B_5_4_selected.jpg
Figure 3 Spleen
(Cells in red pulp
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70395/159850_B_7_4.jpg
(Cells in red pulp
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70395/159850_B_7_4.jpg
Figure 4 RNA cell line category: Cell line enhanced (CACO-2, SK-BR-3)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000049130-KITLG
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000049130-KITLG
Specifications
- Immunogen
- Recombinant human KITLG protein
- Host Species
- Rat
- Type
- Rat IgG2a
- Specificity
- Human KITLG
- Species Reactivity
- Human
- Clone
- 17E8
- Applications
- ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.09% sodium azide
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- KIT Ligand; Mast Cell Growth Factor; Stem Cell Factor; Familial Progressive Hyperpigmentation 2; Steel Factor; C-Kit Ligand; MGF; SCF; DFNA69
- Gene ID
- 4254
- UniProt ID
- P21583
- Long Name
- KIT Ligand
- Sequence Similarities
- Belongs to the SCF family.
- Cellular Localization
- Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Secreted
- Post Translation Modifications
- A soluble form (sKITLG) is produced by proteolytic processing of isoform 1 in the extracellular domain.
Found in two differentially glycosylated forms, LMW-SCF and HMW-SCF. LMW-SCF is fully N-glycosylated at Asn-145, partially N-glycosylated at Asn-90, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97 or Asn-118. HMW-SCF is N-glycosylated at Asn-118, Asn-90 and Asn-145, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97.
A soluble form exists as a cleavage product of the extracellular domain.
- Protein Refseq
- NP_000890.1
- Function
- Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways.
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Isotype Control
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibodies
Fab Antibodies
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Mouse Antibodies
Rabbit Monoclonal Antibodies
Extracellular Vesicle Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-601 | Recombinant Anti-human KITLG Antibody | WB, IF, FuncS | IgG |
| MHH-601 | Recombinant Human Anti-human KITLG Antibody | ELISA, WB, IF, FuncS | IgG |
| MOB-1398CT | Recombinant Mouse anti-Human KITLG Monoclonal antibody (2.3_3I6-2D20) | ELISA | |
| MRO-1369-CN | Recombinant Rabbit Anti-KITLG Monoclonal Antibody (CBACN-497) | WB, IF, IHC, FC | Rabbit IgG |
| VS7-0425-WR223 | Mouse Anti-KITLG Recombinant Antibody (clone 2E1F9) | FC | Mouse IgG2b |
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