Recombinant Mouse Anti-KRT17 Antibody (VS4-CJ5) (CAT#: VS4-CJ5)
This mouse anti-KRT17 antibody is a product that recognizes human KRT17. The immunogen of this antibody is a synthetic peptide corresponding to KRT17. The mAb has been tested for use in ELISA, Western Blot (1:500-1:5000), Immunoprecipitation (1:200-1:2000).
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to intermediate filaments.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/453/27_B11_2_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to intermediate filaments.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/453/27_B11_2_selected.jpg
Figure 2 IF staining of human cell line hTCEpi
(Immunofluorescent staining of human cell line hTCEpi shows localization to intermediate filaments.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/452/1790_A8_1_selected.jpg
(Immunofluorescent staining of human cell line hTCEpi shows localization to intermediate filaments.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/452/1790_A8_1_selected.jpg
Figure 3 High expression in urinary bladder
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/453/1924_A_6_5_val_selected.jpg
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/453/1924_A_6_5_val_selected.jpg
Figure 4 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29/155820_B_8_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29/155820_B_8_5.jpg
Figure 5 RNA cell line category: Group enriched (hTCEpi, SiHa)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128422-KRT17
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128422-KRT17
Specifications
- Immunogen
- Synthetic Peptide
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human KRT17
- Species Reactivity
- Human
- Applications
- ELISA, WB, IP
- Conjugate
- Unconjugated
Product Property
- Purification
- Immunogen affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, PBS, pH 7.4.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Western Blot (1:500-1:5000), Immunoprecipitation (1:200-1:2000).
Target
- Alternative Names
- PC; K17; PC2; 39.1; CK-17; PCHC1; Keratin, type I cytoskeletal 17; Cytokeratin-17; Keratin-17
- Gene ID
- 3872
- UniProt ID
- Q04695
- Long Name
- Keratin 17
- Sequence Similarities
- Belongs to the intermediate filament family.
- Cellular Localization
- Cytoplasm; Intermediate filament; Keratin
- Post Translation Modifications
- Phosphorylation at Ser-44 oCcurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.
- Protein Refseq
- NP_000413.1
- Function
- Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity).
Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity).
Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity).
Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity).
May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Recommended Products
Isotype Control
Secondary Antibody
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1981 | Hi-Affi™ Recombinant Rabbit Anti-KRT17 Monoclonal Antibody (DS1981AB) | ICC/IF, IHC-P, IP, WB | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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