Recombinant Mouse Anti-KRT5 Antibody (clone 5E7-10D10-2C6) (CAT#: VS3-FY828)
This product is a recombinant mouse antibody that recognizes KRT5. This antibody has been reported for use in Immunohistochemistry-Paraffin. The clone 5E7-10D10-2C6 is specific for human KRT5. The antigen is synthetic peptide derived from human cytokeratin 5/6.
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IHC-P
Figure 1. Recombinant Mouse Anti-KRT5 Antibody (clone 5E7-10D10-2C6) in IHC-P.
Immunohistochemical analysis of paraffin-embedded squamous cell lung carcinoma using cytokeratin 5/6 antibody. High pressure and high temperature sodium citrate pH 6.0 for antigen retrieval.
Specifications
- Immunogen
- Synthetic peptide derived from human cytokeratin 5/6.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human KRT5
- Species Reactivity
- Human
- Clone
- 5E7-10D10-2C6
- Applications
- Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Chromatography
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS, pH 7.3, 50% glycerol, 0.5% BSA
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry-Paraffin: 1/100-1/500
Target
- Alternative Names
- Keratin 5; Keratin 5 (Epidermolysis Bullosa Simplex, Dowling-Meara/Kobner/Weber-Cockayne Types); Epidermolysis Bullosa Simplex 2 Dowling-Meara/Kobner/Weber-Cockayne Types; Type-II Keratin Kb5; Keratin 5, Type II; Cytokeratin-5; CK-5; K5; Keratin, Type II Cytoskeletal 5
- Gene ID
- 3852
- UniProt ID
- P13647
- Sequence Similarities
- Belongs to the intermediate filament family.
- Cellular Localization
- Intermediate filament, Keratin
- Post Translation Modifications
- Phosphorylated by CDK1, AURKB and Rho-kinase, phosphorylation is regulated by the cell cycle (By similarity).
Thr-24 phosphorylation, mediated by CDK1, peaks during prometaphase or metaphase cells with phosphorylated filamentous structures evident throughout the cytoplasm during early mitosis (By similarity).
CDK1 phosphorylates Thr-24 in mitotic cells at the site of injury (By similarity).
- Protein Refseq
- NP_000415.2
- Function
- Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity).
Recommended Products
Secondary Antibody
Isotype Control
Reconstitution Buffer
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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See other products for "KRT5/KRT6A"
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0405U | Rabbit Anti-KRT5/KRT6A Recombinant Antibody (clone T16-K) | IHC-P | Rabbit IgG |
| VS4-CJ9 | Recombinant Mouse Anti-KRT5/KRT6A Antibody (VS4-CJ9) | ELISA, IHC | Mouse IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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