Recombinant Mouse Anti-KRT5/KRT6A Antibody (VS4-CJ9) (CAT#: VS4-CJ9)

• Immunogen
• Synthesized peptide derived from human Cytokeratin 5/6

• Host Species
• Mouse

• Type
• Mouse IgG1, κ

• Specificity
• Human KRT5/KRT6A

• Species Reactivity
• Human

• Applications
• ELISA, IHC

• Conjugate
• Unconjugated

• Purification
• Immunogen affinity chromatography

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Buffer
• 50% Glycerol, 0.5% BSA, PBS

• Preservative
• 0.02% Sodium Azide

• Storage
• Store at -20°C or -80°C upon receipt. Avoid repeated freeze.

• Application Notes
• This antibody has been tested for use in ELISA, Immunohistochemistry (1:20-1:200).

• Alternative Names
• K5; CK5; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B; EBS2C; EBS2D; EBS2E; EBS2F; KRT5A; K6A; KRT6D; Keratin type II cytoskeletal 6A; Cytokeratin-6A; CK-6A; Cytokeratin-6D; CK-6D; Keratin-6A; K6A; Type-II keratin Kb6; allergen Hom s 5; KRT6B; K6B; KRTL1; Keratin type II cytoskeletal 6B; Cytokeratin-6B; CK-6B; Keratin-6B; K6B; Type-II keratin Kb10; KRT6C; KRT6E; Keratin type II cytoskeletal 6C; Cytokeratin-6C; CK-6C; Cytokeratin-6E; CK-6E; Keratin K6h; Keratin-6C; K6C; Type-II keratin Kb12; K6D; PC3

• Gene ID
• 3852; 3853

• UniProt ID
• P13647

• Long Name
• Keratin 5/6A

• Sequence Similarities
• Belongs to the intermediate filament family.

• Cellular Localization
• Intermediate filament, Keratin

• Post Translation Modifications
• Phosphorylated by CDK1, AURKB and Rho-kinase, phosphorylation is regulated by the cell cycle (By similarity).
  Thr-24 phosphorylation, mediated by CDK1, peaks during prometaphase or metaphase cells with phosphorylated filamentous structures evident throughout the cytoplasm during early mitosis (By similarity).
  CDK1 phosphorylates Thr-24 in mitotic cells at the site of injury (By similarity).

• Protein Refseq
• NP_000415.2

• Function
• Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity).

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Select a product category from the dropdown menu below to view related products.