Recombinant Rabbit Anti-LAMP1 Antibody (clone R05-7D4)
CAT#: VS3-FY837
This product is a recombinant rabbit antibody that recognizes LAMP1. This antibody has been reported for use in Western Blot, Immunohistochemistry-Paraffin. The clone R05-7D4 is specific for human LAMP1. The antigen is synthetic peptide of human lamp1.
Gene Expression
Tested Data
Normal Tissue
Figure 1 Ihc staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows strong granular positivity in urothelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14750/34136_A_5_5_selected.jpg
Normal Tissue
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows strong cytoplasmic positivity(granular pattern) in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_B_9_5.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_8_4.jpg
Normal Tissue
Figure 5 Pancreas
Exocrine glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_1_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000185896-LAMP1
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WB
Figure 1. Recombinant Rabbit Anti-LAMP1 Antibody (clone R05-7D4) in WB.
Western Blot analysis of LAMP1 in HeLa lysates using LAMP1 antibody.
IHC-P
Figure 2. Recombinant Rabbit Anti-LAMP1 Antibody (clone R05-7D4) in IHC-P.
Immunohistochemical analysis of paraffin-embedded human tonsil using LAMP1 antibody. High pressure and high temperature sodium citrate pH 6.0 for antigen retrieval.
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Specifications
- Immunogen
- Synthetic peptide of human LAMP1.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human LAMP1
- Species Reactivity
- Human
- Clone
- R05-7D4
- Applications
- Western Blot, Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
- MW
- Calculated MW: 45 kDa; Observed MW: 90-120 kDa
Product Property
- Purification
- Affinity Purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry-Paraffin: 1/50-1/100
Target
- Alternative Names
- LAMP1; Lysosome-associated membrane glycoprotein 1; LAMP-1; Lysosome-associated membrane protein 1; CD107 antigen-like family member A; CD107a
- Gene ID
- 3916
- Sequence Similarities
- Belongs to the LAMP family.
- Cellular Localization
- Cell membrane, Endosome, Lysosome, Membrane
- Post Translation Modifications
- O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells.
- Protein Refseq
- NP_005552.3
- Function
- Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis (By similarity).
Also plays an important role in NK-cells cytotoxicity (PubMed:23632890, PubMed:2022921).
Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890).
In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195).
Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasisBy Similarity3 Publications
(Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085).
Promotes also fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909).2 Publications
(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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| HPAB-0035-LSX-F(E) | Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0035-LSX-F(E)) | ELISA, IHC | Chimeric (mouse/human) Fab |
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| HPAB-0035-LSX-S(P) | Human Anti-LAMP1 Recombinant Antibody; scFv Fragment (HPAB-0035-LSX-S(P)) | ELISA, IHC | Human scFv |
| HPAB-0036-LSX-S(P) | Human Anti-LAMP1 Recombinant Antibody; scFv Fragment (HPAB-0036-LSX-S(P)) | ELISA, IHC | Human scFv |
| HPAB-0037-LSX-S(P) | Mouse Anti-LAMP1 Recombinant Antibody; scFv Fragment (HPAB-0037-LSX-S(P)) | ELISA, IHC | Mouse scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0035-LSX | Human Anti-LAMP1 Recombinant Antibody (HPAB-0035-LSX) | ELISA, IHC, ADCC | Human IgG |
| HPAB-0036-LSX | Human Anti-LAMP1 Recombinant Antibody (HPAB-0036-LSX) | ELISA, IHC, ADCC, FuncS | Human IgG |
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| HPAB-0038-LSX | Human Anti-LAMP1 Recombinant Antibody (HPAB-0038-LSX) | ELISA, IHC, FC, ADCC, FuncS | Human IgG |
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| CAT | Product Name | Application | Type |
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