Recombinant Rabbit Anti-LAMP1 Antibody (clone R05-7D4) (CAT#: VS3-FY837)
This product is a recombinant rabbit antibody that recognizes LAMP1. This antibody has been reported for use in Western Blot, Immunohistochemistry-Paraffin. The clone R05-7D4 is specific for human LAMP1. The antigen is synthetic peptide of human lamp1.
Specific Inquiry
WB
Figure 1. Recombinant Rabbit Anti-LAMP1 Antibody (clone R05-7D4) in WB.
Western Blot analysis of LAMP1 in HeLa lysates using LAMP1 antibody.
IHC-P
Figure 2. Recombinant Rabbit Anti-LAMP1 Antibody (clone R05-7D4) in IHC-P.
Immunohistochemical analysis of paraffin-embedded human tonsil using LAMP1 antibody. High pressure and high temperature sodium citrate pH 6.0 for antigen retrieval.
Specifications
- Immunogen
- Synthetic peptide of human LAMP1.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human LAMP1
- Species Reactivity
- Human
- Clone
- R05-7D4
- Applications
- Western Blot, Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
- MW
- Calculated MW: 45 kDa; Observed MW: 90-120 kDa
Product Property
- Purification
- Affinity Purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry-Paraffin: 1/50-1/100
Target
- Alternative Names
- LAMP1; Lysosome-associated membrane glycoprotein 1; LAMP-1; Lysosome-associated membrane protein 1; CD107 antigen-like family member A; CD107a
- Gene ID
- 3916
- Sequence Similarities
- Belongs to the LAMP family.
- Cellular Localization
- Cell membrane, Endosome, Lysosome, Membrane
- Post Translation Modifications
- O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells.
- Protein Refseq
- NP_005552.3
- Function
- Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis (By similarity).
Also plays an important role in NK-cells cytotoxicity (PubMed:23632890, PubMed:2022921).
Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890).
In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195).
Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasisBy Similarity3 Publications
(Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085).
Promotes also fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909).2 Publications
(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "LAMP1"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-611 | Recombinant Anti-human LAMP1 Antibody | ELISA, WB, FC, FuncS | IgG |
| MHH-611 | Recombinant Human Anti-human LAMP1 Antibody | WB, IF, FuncS | IgG |
| MOB-1060CT | Recombinant Mouse anti-Human LAMP1 Monoclonal antibody (C-U58) | FC | |
| MRO-0916-CN | Recombinant Rabbit Anti-LAMP1 Monoclonal Antibody (JJ0940) | WB, IHC | Rabbit IgG |
| VS3-CJ587 | Mouse Anti-LAMP1 Recombinant Antibody (VS3-CJ587) | WB, ICC, IHC | Mouse IgG1, κ |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-611-F(E) | Recombinant Anti-human LAMP1 Antibody Fab Fragment | IF, FuncS | Fab |
| MHH-611-F(E) | Recombinant Human Anti-human LAMP1 Antibody Fab Fragment | WB, Neut, FuncS | Fab |
| HPAB-0035-LSX-F(E) | Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0035-LSX-F(E)) | ELISA, IHC | Chimeric (mouse/human) Fab |
| HPAB-0036-LSX-F(E) | Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0036-LSX-F(E)) | ELISA, IHC | Chimeric (mouse/human) Fab |
| HPAB-0037-LSX-F(E) | Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0037-LSX-F(E)) | ELISA, IHC | Chimeric (mouse/human) Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-611-S(P) | Recombinant Anti-human LAMP1 Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| MHH-611-S(P) | Recombinant Human Anti-human LAMP1 Antibody scFv Fragment | ELISA, WB, FC, FuncS | scFv |
| HPAB-0035-LSX-S(P) | Human Anti-LAMP1 Recombinant Antibody; scFv Fragment (HPAB-0035-LSX-S(P)) | ELISA, IHC | Human scFv |
| HPAB-0036-LSX-S(P) | Human Anti-LAMP1 Recombinant Antibody; scFv Fragment (HPAB-0036-LSX-S(P)) | ELISA, IHC | Human scFv |
| HPAB-0037-LSX-S(P) | Mouse Anti-LAMP1 Recombinant Antibody; scFv Fragment (HPAB-0037-LSX-S(P)) | ELISA, IHC | Mouse scFv |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2010 | Hi-Affi™ Recombinant Rabbit Anti-LAMP1 Monoclonal Antibody (DS2010AB) | WB, IHC | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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