Recombinant Anti-LAMP3 Vesicular Antibody, EV Displayed (VS-0425-YC702) (CAT#: VS-0425-YC702)
The Recombinant Anti-LAMP3 Vesicular Antibody, EV Displayed (VS-0425-YC702) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to LAMP3-expressed cells or tissues. LAMP3 is expressed in dendritic cells, playing roles in antigen presentation and the immune response.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/51467/806_E8_1_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/51467/806_E8_1_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25133/950_A1_1_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25133/950_A1_1_selected.jpg
Figure 3 IHC staining of human lung
(High expression. RNA expression: 219.7 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/51467/ihc_selected.jpg
(High expression. RNA expression: 219.7 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/51467/ihc_selected.jpg
Figure 4 IHC staining of human kidney
(Low expression. RNA expression: 0.6 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/51467/124392_A_8_5_val_selected.jpg
(Low expression. RNA expression: 0.6 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/51467/124392_A_8_5_val_selected.jpg
Figure 5 Colon
(Endothelial cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/51467/124392_A_7_3.jpg
(Endothelial cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/51467/124392_A_7_3.jpg
Figure 6 Lymph node
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/51467/124392_A_9_8.jpg
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/51467/124392_A_9_8.jpg
Figure 7 RNA cell line category: Group enriched (EFO-21, HDLM-2, HHSteC, hTCEpi, JURKAT)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000078081-LAMP3
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000078081-LAMP3
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- LAMP3
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Lysosomal associated membrane protein 3
- Biological Process
- Adaptive immunity, Host-virus interaction, Immunity
- Cellular Localization
- Vesicles
- Introduction
- Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses.
- Alternative Names
- CD208, DC-LAMP, DCLAMP, LAMP, TSC403
- Gene ID
- 27074
- UniProt ID
- Q9UQV4
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2032z | Mouse Anti-LAMP3 Recombinant Antibody (clone 33A4) | WB, FC, IF | Mouse IgG2a, κ |
| FAMAB-1372CQ | Human Anti-LAMP3 Recombinant Antibody (clone L3P2H10*E3) | WB, IHC | Human IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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